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GLP-1 Agonists peptide therapy
Weight & MetabolicHigh: multiple RCTs

GLP-1 Agonists Peptide Therapy

Benefits, Side Effects, Cost & Protocols

Also known as: Semaglutide, Tirzepatide

GLP-1 Agonists injection vial product photoGLP-1 Agonists peptide molecular structure diagram from PubChem

Mimics the GLP-1 hormone to regulate appetite, slow gastric emptying, and improve insulin sensitivity. Gold standard for sustainable weight loss.

ByChris Riley(CFA)&Alex Evans, PharmD, MBA(PharmD, MBA)|Updated

Clinically Reviewed

Reviewed by Alex Evans, PharmD, MBA · Updated May 2026

Evidence-Based

Sourced from FDA, PubMed & ClinicalTrials.gov · View sources

Typical Cost
$200–$500/mo
FDA Status
FDA-approved (semaglutide, tirzepatide)
Evidence
High: multiple RCTs
Category
Weight & Metabolic
Peptides for Weight LossPeptides for Fat Loss

Compare GLP-1 Agonists Prices

54 providers offering GLP-1 Agonists — sorted lowest price first

Lowest Price
TeleHealth Med
Compounded Semaglutide
503A CompoundedClinical
$147
/month
Get Started
Direct Meds
Semaglutide· weekly injection
503A CompoundedClinical
$147
/month
Get Started
Silhouette MD
Semaglutide Injection
503A CompoundedClinical
$149
/month
Get Started
Hims
Wegovy® Pill
503A CompoundedClinical
$149
/month
Get Started
Direct Meds
Tirzepatide Oral Drops
503A CompoundedClinical
$149
/month
Get Started
Direct Meds
Semaglutide Oral Drops
503A CompoundedClinical
$149
/month
Get Started
TrimRx
Injectable Semaglutide
503A CompoundedClinical
$179
/month
Get Started
TrimRx
Oral Semaglutide
503A CompoundedClinical
$179
/month
Get Started
Clinic Secret
Compounded Semaglutide· $49/week
503A CompoundedClinical
$196
/month
Get Started
PeterMD
Semaglutide Injection· 0.25mg-2.4mg weekly
ClinicalRx
$197
/month
Get Started
TeleHealth Med
Compounded Tirzepatide
503A CompoundedClinical
$199
/month
Get Started
Hims
Wegovy® Pen
503A CompoundedClinical
$199
/month
Get Started
Hims
Ozempic®
503A CompoundedClinical
$199
/month
Get Started
ShedRX
Compounded Semaglutide Injection
503A CompoundedClinical
$199
/month
Get Started
ShedRX
GLP-1 Lozenges
503A CompoundedClinical
$199
/month
Get Started
BrightMeds
Semaglutide· weekly injection
ClinicalRx
$215
/month
Get Started
BreezeMeds
Semaglutide· weekly injection
503A CompoundedClinical
$225
/month
Get Started
ShedRX
GLP-1 Liquid Drops
503A CompoundedClinical
$229
/month
Get Started
Blue Sky MD
Semaglutide Weight Loss· weekly injection
Clinical
$249
/month
Get Started
Alpha Hormones
Semaglutide· weekly injection
ClinicalRx
$249
/month
Get Started
Better Life Medical
Semaglutide· weekly injection
Clinical
$259
/month
Get Started
Silhouette MD
Semaglutide Oral
503A CompoundedClinical
$263
/month
Get Started
Belle Health
Semaglutide· weekly injection
ClinicalRx
$275
/month
Get Started
Defy Medical
Semaglutide Injection· 0.25mg-2.4mg weekly
ClinicalRx
$289
/month
Get Started
Willow
Semaglutide Oral
503A CompoundedClinical
$299
/month
Get Started
Hims
Generic Liraglutide
503A CompoundedClinical
$299
/month
Get Started
VivioMDOut of Stock
GLP-1 Tablets (Semaglutide)
FDA BrandClinical
$299
/month
Get Started
Prime Health
Compounded Semaglutide
503A CompoundedClinical
$299
/month
Get Started
ShedRX
Compounded Tirzepatide Injection
503A CompoundedClinical
$299
/month
Get Started
Hone Health
Semaglutide Program· 0.25mg-2.4mg weekly
ClinicalRx
$299
/month
Get Started
Calibrate
Calibrate Semaglutide· weekly injection
ClinicalRx
$299
/month
Get Started
ShedRX
Oral Semaglutide Tablets
503A CompoundedClinical
$299
/month
Get Started
ReadyRx
Compounded Semaglutide
503A CompoundedClinical
$299
/month
Get Started
Willow
Semaglutide Injectable
503A CompoundedClinical
$299
/month
Get Started
Silhouette MD
Tirzepatide Injection
503A CompoundedClinical
$299
/month
Get Started
Silhouette MD
Tirzepatide Oral
503A CompoundedClinical
$325
/month
Get Started
BodyLogicMD
Semaglutide Program· weekly injection
Research Use
$325
/month
Get Started
TrimRx
Oral Tirzepatide (GLP-1+GIP)
503A CompoundedClinical
$330
/month
Get Started
Ageless Rx
Semaglutide· weekly injection
Research Use
$349
/month
Get Started
TrimRx
Injectable Tirzepatide (GLP-1+GIP)
503A CompoundedClinical
$349
/month
Get Started
PeterMD
Tirzepatide Injection· 2.5mg-15mg weekly
ClinicalRx
$349
/month
Get Started
Alpha Hormones
Tirzepatide· weekly injection
ClinicalRx
$379
/month
Get Started
VivioMD
GLP-1 Injection (Semaglutide)
FDA BrandClinical
$398
/month
Get Started
Blue Sky MD
Tirzepatide Weight Loss· weekly injection
Clinical
$399
/month
Get Started
Calibrate
Calibrate Tirzepatide· weekly injection
ClinicalRx
$399
/month
Get Started
Defy Medical
Tirzepatide Injection· 2.5mg-15mg weekly
ClinicalRx
$399
/month
Get Started
ReadyRx
Compounded Tirzepatide
503A CompoundedClinical
$399
/month
Get Started
Willow
Tirzepatide Injectable
503A CompoundedClinical
$399
/month
Get Started
Prime Health
Compounded Tirzepatide
503A CompoundedClinical
$399
/month
Get Started
Clinic Secret
Compounded Tirzepatide
503A CompoundedClinical
$427
/month
Get Started
Hone Health
Tirzepatide Program· 2.5mg-15mg weekly
ClinicalRx
$449
/month
Get Started
BodyLogicMD
Tirzepatide Program· weekly injection
Research Use
$475
/month
Get Started
Direct Meds
Tirzepatide· weekly injection
503A CompoundedClinical
$497
/month
Get Started
VivioMD
GLP-1+GIP Injection (Tirzepatide)
FDA BrandClinical
$1299
/month
Get Started

Prices shown are estimates based on publicly available data and may not reflect current pricing. Actual costs may vary by location, insurance, dosage, and formulation. Always verify directly with the provider.

Who Is GLP-1 Agonists Best For?

Weight lossType 2 diabetesMetabolic syndrome

GLP-1 Agonists Compound Data

GLP-1 Agonists peptide chemical structure and molecular formula from PubChem
Molecular Formula
C149H226N40O45
Molecular Weight
3297.6 g/mol
IUPAC Name
(4S)-5-[[2-[[(1S,2R)-1-[[(1S)-2-[[(1S,2R)-1-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[2-[[(1S)-4-amino-1-[[(1S)-2-[[(1S)-2-[[(1S)-5-amino-1-[[(1S)-1-[[(1S)-2-[[(1S,2S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-5-amino-1-[[2-[[(1S)-1-carbamoyl-4-guanidino-butyl]amino]-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-methyl-butyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-3-carboxy-propyl]carbamoyl]pentyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-oxo-butyl]amino]-2-oxo-ethyl]carbamoyl]-3-carboxy-propyl]carbamoyl]-3-methyl-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-2-oxo-ethyl]amino]-4-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]propanoyl]amino]-5-oxo-pentanoic acid
View full compound on PubChem

GLP-1 Agonists News

Glucagon-like peptide-1 receptor agonists for major cardiovascular and kidney outcomes in type 1 diabetes - Nature

Nature · 2 months ago

GLP-1 receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits - The Lancet

The Lancet · 4 months ago

Glucagon-like peptide-1 agonists’ effects on glycemic control, weight loss, and beta cells function in type 1 diabetes - Frontiers

Frontiers · 2 months ago

What do GLP-1 receptor agonists actually do? - VCU Health

VCU Health · 10 months ago

SGLT2 vs GLP-1: Individualizing Diabetes, Cardiovascular, and Renal Outcomes - Clinical Advisor

Clinical Advisor · 3 days ago

News aggregated via Google News. Inclusion does not imply endorsement.

GLP-1 Agonists Articles & Guides

In-depth articles about GLP-1 Agonists and related peptide therapies.

What Is Compounded Semaglutide? Safety, Cost & Where to Get It (2026)

Learn what compounded semaglutide is, whether it's safe, how much it costs vs brand-name Wegovy, and where to find verified compounding pharmacies in 2026.

Read article →

Cheapest Semaglutide Without Insurance: Price Comparison (2026)

Find the lowest semaglutide prices without insurance. Compare compounded semaglutide costs from $149/mo across verified telehealth providers. Updated April 2026.

Read article →

Tirzepatide vs Semaglutide: Which GLP-1 Is Better for Weight Loss?

Head-to-head comparison of tirzepatide (Mounjaro/Zepbound) vs semaglutide (Wegovy/Ozempic) for weight loss. Efficacy, side effects, cost & provider options in 2026.

Read article →

Semaglutide Dose Chart: Complete Titration Schedule & Dosing Guide (2026)

Complete semaglutide dosing chart with titration schedules for weight loss and compounded formulations. Week-by-week guide from 0.25mg to maintenance dose.

Read article →

Peptide Weight Loss Side Effects: What to Expect & How to Manage Them

Common and serious side effects of weight loss peptides including GLP-1s, AOD-9604, and CJC-1295. What to expect, when to worry, and management tips.

Read article →

Best Peptides for Belly Fat: AOD-9604, MOTS-C & Targeted Fat Loss (2026)

Which peptides target stubborn belly fat? Compare AOD-9604, MOTS-C, and GLP-1 peptides for targeted fat metabolism. Protocols, costs, and provider options.

Read article →

Explore all articles and provider comparisons:

Peptides for Weight Loss →Peptides for Fat Loss →

Related Peptides in Weight & Metabolic

AOD-9604

A modified fragment (amino acids 177-191) of human growth hormone targeting fat metabolism. Stimulates lipolysis without the growth or blood sugar effects of full HGH.

Browse all peptides in our encyclopedia →
Medical Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. Peptide therapies have not been evaluated by the FDA for most listed indications.All prices shown are estimates based on publicly available data and may not reflect current pricing — providers and brands set their own prices and can change them at any time. Always verify pricing directly with the provider before purchasing. Consult a licensed healthcare provider before starting any peptide protocol.

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