PT-141
Peptide therapy: benefits, side effects, cost and protocols
Bremelanotide (PT-141), sold under the brand name Vyleesi, is a medication used to treat hypoactive sexual desire disorder (HSDD) in premenopausal women. It is a melanocortin receptor agonist given by subcutaneous injection.
Sources: FDA / PubMed / ClinicalTrials.gov View
Spec sheet
- Lowest listed
- $99/mo
- FDA status
- FDA Approved June 2019 FDA approved as Vyleesi (bremelanotide) for hypoactive sexual desire disorder in premenopausal women. Also compounded.
- Evidence
- Strong Evidence
Price sheet
PT-141 prices, lowest first
3 listings, $99 to $159 per month.
We may earn a commission at no extra cost to you. Disclosure
| Provider | Per month | Link |
|---|---|---|
PeterMD PT-141 Injection / 1.75mg as needed ClinicalRx | $99Lowest | Visit |
Defy Medical PT-141 (Bremelanotide) / 1.75mg as needed ClinicalRx | $125 | Visit |
Ageless Rx PT-141 / as needed Research Use | $159 | Visit |
Prices shown are estimates based on publicly available data and may not reflect current pricing. Actual costs may vary by location, insurance, dosage, and formulation. Always verify directly with the provider.
Mechanism
How PT-141 works
Melanocortin-4 receptor agonist that activates sexual arousal pathways in the brain, working differently from PDE5 inhibitors.
Evidence
Key studies
121 papers on PubMed / 91 human trials
- 01
Safety Profile of Bremelanotide Across the Clinical Development Program
- 02
Clayton AH, Kingsberg SA, Portman D et al
J Womens Health (Larchmt) / Phase 3
Bremelanotide shows mostly mild-to-moderate adverse events; nausea most common reason for discontinuation.
- 03
Bremelanotide shows mostly mild-to-moderate adverse events; nausea most common reason for discontinuation
- 04
Prespecified and Integrated Subgroup Analyses from the RECONNECT Phase 3 Studies of Bremelanotide
- 05
Simon JA, Kingsberg SA, Portman D et al
J Womens Health (Larchmt) / Phase 3
Bremelanotide improved sexual desire and reduced distress across multiple demographic and clinical subgroups.
- 06
Bremelanotide improved sexual desire and reduced distress across multiple demographic and clinical subgroups
- 07
Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials
- 08
Kingsberg SA, Clayton AH, Portman D et al
Obstet Gynecol / Obstet Gynecol / Phase 3
Bremelanotide significantly increased sexual desire and reduced distress in premenopausal women with hypoactive sexual desire disorder.
- 09
Bremelanotide significantly increased sexual desire and reduced distress in premenopausal women with hypoactive sexual desire disorder
- 10
Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder
Compound
PT-141 compound data
- Formula
- C50H68N14O10
- Mol. weight
- 1025.2 g/mol
- PubChem CID
- 9941379 ↗
- IUPAC
- (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-(3-guanidinopropyl)-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxylic acid
FAQ
PT-141 questions
What is PT-141?
PT-141 (Bremelanotide) is a melanocortin peptide approved and available through compounding pharmacies for sexual dysfunction. It works through the central nervous system rather than the vascular system.
How does PT-141 work?
Melanocortin-4 receptor agonist that activates sexual arousal pathways in the brain, working differently from PDE5 inhibitors.
Is PT-141 legal to buy?
PT-141 requires a prescription from a licensed healthcare provider. It is legal to purchase with a valid prescription from authorized pharmacies.
Where can I buy PT-141?
PT-141 is available by prescription through compounding pharmacies and telehealth providers. Browse our verified provider directory to find trusted sources.
What category does PT-141 belong to?
PT-141 is primarily classified as a sexual function & libido peptide. Peptides researched for their effects on sexual function, libido, and reproductive health.
What are the research benefits of PT-141?
PT-141 has been studied for: Sexual function, Libido enhancement, Arousal support. Bremelanotide; available via compounding pharmacies for libido.
News
PT-141 in the news
Peptides for erectile dysfunction (ED): safety, efficacy, and more - Ro
Ro / 3 months ago
Watch Biomedical Scientist Debunks The Biggest Peptide Myths on Reddit - WIRED
WIRED / 7 days ago
What Are Peptides and Do They Work? BPC-157, Tesamorelin, and Tanning Peptides Explained - Los Angeles Times
Los Angeles Times / 2 months ago
The online ‘sex peptide’ market is growing. So are the health risks - MDLinx
MDLinx / 19 days ago
Sexmaxxing in the city: The SF biohackers injecting peptides into their sex lives - The San Francisco Standard
The San Francisco Standard / 2 months ago
News aggregated via Google News. Inclusion does not imply endorsement.
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