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Growth Hormone SecretionModerate evidence

CJC-1295

Peptide therapy: benefits, side effects, cost and protocols

29 aa / 3,647.2 g/mol / CID 91971820 / Mod GRF(1-29), a = D-Ala
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CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH) and a growth hormone secretagogue developed by ConjuChem Biotechnologies. It is a modified form of GHRH (1-29) with improved pharmacokinetics, especially in regard to half-life.

ByChris Riley(CFA)|Updated

Sources: FDA / PubMed / ClinicalTrials.gov View

Spec sheet

FDA status
Compounding Allowed Currently on FDA bulk drug substance nomination list for compounding. GHRH analog used in combination protocols.
Evidence
Moderate Evidence
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Who it's for

Who CJC-1295 is usually considered for

  • Growth hormone secretion
  • Muscle support
  • Recovery
  • Anti-aging research
  • Body composition
  • 1 preclinical study
  • Limited human trials or strong preclinical

Mechanism

How CJC-1295 works

Stimulates the pituitary gland to release growth hormone by mimicking natural GHRH signaling. The DAC version provides sustained release while the non-DAC version allows more natural pulsatile patterns.

Evidence

Key studies

33 papers on PubMed / 21 human trials

  1. 01

    Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects

  2. 02

    Sackmann-Sala L, Ding J, Frohman LA et al

    Growth Horm IGF Res / Growth Horm IGF Res / Phase 1

    CJC-1295 altered serum protein profiles including apolipoprotein A1 and transthyretin as potential GH/IGF-1 biomarkers.

  3. 03

    CJC-1295 altered serum protein profiles including apolipoprotein A1 and transthyretin as potential GH/IGF-1 biomarkers

  4. 04

    Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults

  5. 05

    Teichman SL, Neale A, Lawrence B et al

    J Clin Endocrinol Metab / Phase 1

  6. 06

    CJC-1295 produced sustained dose-dependent increases in GH and IGF-I levels with good safety profile

  7. 07

    Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog

    J Clin Endocrinol Metab / Phase 1

  8. 08

    CJC-1295 increased GH and IGF-I levels while preserving normal GH pulsatile secretion patterns

  9. 09

    The study of doping market: How to produce intelligence from Internet forums

  10. 10

    Pineau T, Schopfer A, Grossrieder L et al

    Forensic Sci Int / Forensic Sci Int

Compound

CJC-1295 compound data

Formula
C165H269N47O46
Mol. weight
3647.2 g/mol
PubChem CID
91971820 ↗
IUPAC
(3S)-4-[[(1S)-2-[[(1S,2S)-1-[[(1S)-2-[[(1S,2R)-1-[[(1S)-4-amino-1-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-5-amino-1-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-4-amino-1-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-5-amino-1-[[(1S)-1-[[(1S)-1-[[(1S)-4-amino-1-[[(1S)-2-[[(1S,2S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-1-carbamoyl-5-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]pentyl]carbamoyl]-4-guanidino-butyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-methyl-butyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]carbamoyl]-4-oxo-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]pentyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-4-oxo-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-methyl-propyl]carbamoyl]pentyl]carbamoyl]-4-guanidino-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-4-oxo-butyl]carbamoyl]-2-hydroxy-propyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-3-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-4-oxo-butanoic acid

FAQ

CJC-1295 questions

What is CJC-1295?

CJC-1295 is a growth hormone-releasing hormone (GHRH) analog available in two forms: with DAC (Drug Affinity Complex) for extended half-life, and without DAC (MOD GRF 1-29) for more pulsatile release. It's one of the most established peptides for growth hormone research.

How does CJC-1295 work?

Stimulates the pituitary gland to release growth hormone by mimicking natural GHRH signaling. The DAC version provides sustained release while the non-DAC version allows more natural pulsatile patterns.

Is CJC-1295 legal to buy?

CJC-1295 requires a prescription from a licensed healthcare provider. It is legal to purchase with a valid prescription from authorized pharmacies.

Where can I buy CJC-1295?

CJC-1295 is available through compounding pharmacies with a valid prescription. Our directory lists verified pharmacies that compound this peptide.

What category does CJC-1295 belong to?

CJC-1295 is primarily classified as a growth hormone secretion peptide. Peptides that stimulate or support growth hormone release, including GHRH analogs, GHRPs, and direct GH compounds for muscle, recovery, and anti-aging research.

What are the research benefits of CJC-1295?

CJC-1295 has been studied for: Growth hormone secretion, Muscle support, Recovery, Anti-aging research, Body composition. Classic GHRH analog; available in compounding pharmacies.

News

CJC-1295 in the news

News aggregated via Google News. Inclusion does not imply endorsement.

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