April 22, 2026
Wednesday, April 22, 2026
Today: 8 trending tweets, 8 new studies.
New Research
Pilot study of epigenetic aging and treatment response to semaglutide in the SLIM LIVER study.
npj aging
The effects of GLP-1 receptor agonists on Alzheimer's pathophysiology: A systematic review.
Molecular and cellular neurosciences
Cost-Effectiveness of Incretin Therapies: A Canadian Lens on Diabetes, Obesity, and Emerging Indications.
Canadian journal of physiology and pharmacology
Cost-effectiveness of tirzepatide versus semaglutide for patients with obesity or overweight in the US: evidence from the SURMOUNT-5 head-to-head phase-3 trial.
Journal of medical economics
Integrated Evidence from VigiBase and Clinical Trials: A Comprehensive Pharmacovigilance Analysis of Seven Glucagon-Like Peptide 1 Receptor Agonists (GLP-1 RAs).
Diabetes therapy : research, treatment and education of diabetes and related disorders
Rapid remission of Hailey-Hailey disease with tirzepatide therapy: A case report.
JAAD case reports
Dynamics of Body Composition and Metabolic Risk in Adolescents With Obesity Under GLP-1 Receptor Agonist Therapy.
Acta paediatrica (Oslo, Norway : 1992)
A novel, widespread impurity in mass-compounded tirzepatide/b12 products: patient safety implications.
Expert opinion on drug safety
Trending on X
BEST PEPTIDES: S-Tier: Tirzepatide, Tesamorelin, Oxytocin A-Tier: Semaglutide, Sermorelin, Melanotan 1 B-Tier: NAD+ C-Tier: Everything else due to purity issues, until they can be legally compounded by US pharmacies (e.g. Retatrutide, BPC-157, TB-4, CJC, MT2, MOTS-c, etc.)
SKIP HYPE: If you want to HEAL faster, Skip BPC-157 (poor data) Take a Growth Hormone peptide (TESAMORELIN) If you want to lose FAT, Skip Reta (stimulates the heart) Take a GLP-1/GIP (TIRZEPATIDE) If you want to feel CALM, Skip Selank (poor data) Take a neuropeptide (OXYTOCIN)
@TheLongInvest For now, it's $HIMS. But I suspect it'll be $AVCT #AVCT in the not-too-distant future. The large majority of US retail associate #peptides with the GLP-1 mimetics (semaglutide, tirzepatide) and bioregulatory / research peptides (e.g. BPC-157; TB-500; GHK-Cu, etc.). But the
Amazon just launched a GLP-1 program through One Medical. $149/mo oral. $299/mo injectable. But GLP-1s are one peptide class out of dozens. BPC-157, Thymosin Beta-4, GHK-Cu, MOTS-c... the real wave hasn't even started. The FDA is deregulating 12+ peptides. Amazon is entering https://t.co/NqBTc9WhHt
🚨 $HIMS +46% in 1 week as FDA schedules peptide compounding review (July 23–24) The FDA will evaluate 7 peptides for compounding eligibility: → BPC-157, KPV, TB-500, MOTs-C, Emideltide, Semax, Epitalon ✅Hims & Hers CMO called it an “avenue toward trusted channels” This is https://t.co/yKIFM6lEZh
Did a bit of research and seems like these are most used peptides: -tirzepatide -semaglutide -BPC-157 -TB-500 -ipamorelin What do you think of peptides?
🚨 $KITL BULLISH ALERT: FDA Peptide Reversal = Massive Catalyst for the OTC Pioneer! With RFK Jr. at HHS and the FDA now actively weighing the lift on restrictions for ~14 key peptides (BPC-157, TB-500, CJC-1295, GHK-Cu, and more), the gray-market peptide era is ending — and
• HHS Secretary Kennedy just announced the FDA is removing 12 key peptides from Category 2 restrictions starting with BPC-157 and others moving to full scientific review. • $HIMS is not a GLP-1 only company. The entire peptide industry stands ready to boom as regulated access https://t.co/3HzcTJWfS0 https://t.co/9UySm2FWBU
Provider Spotlight
Direct Meds
Direct Meds offers prescription semaglutide and tirzepatide (generic for Ozempic and Mounjaro) with telehealth consults, medication, supplies, and 1-2 day shipping included in one monthly price. Available as injections or oral sublingual drops. No insurance required, HSA accepted. Serves all US states except Mississippi and Louisiana.