Tesofensine
Peptide therapy: benefits, side effects, cost and protocols
C17H23Cl2NO
Tesofensine is a novel triple monoamine reuptake inhibitor (serotonin, norepinephrine, dopamine) originally developed for neurodegenerative diseases that demonstrated significant weight loss effects in clinical trials. It reduces appetite and increases metabolic rate through central nervous system mechanisms.
Sources: FDA / PubMed / ClinicalTrials.gov View
Spec sheet
- FDA status
- Research Only Not currently approved for human use in the US. Available as a research compound. Not eligible for compounding.
- Evidence
- Strong Evidence
Who it's for
Who Tesofensine is usually considered for
- Significant weight loss potential
- Appetite suppression
- Increased satiety
- Potential cognitive benefits
Mechanism
How Tesofensine works
Inhibits reuptake of serotonin, norepinephrine, and dopamine, leading to reduced appetite, increased satiety, and potentially enhanced fat metabolism. Different mechanism than GLP-1 agonists.
Evidence
Key studies
56 papers on PubMed / 44 human trials
- 01
Quantitative pharmacology approach in Alzheimer's disease: efficacy modeling of early clinical data to predict clinical outcome of tesofensine
- 02
Lehr T, Staab A, Trommeshauser D et al
AAPS J / Phase 2
PK/PD modeling predicted negative outcome of tesofensine phase IIb trial in Alzheimer's disease.
- 03
PK/PD modeling predicted negative outcome of tesofensine phase IIb trial in Alzheimer's disease
- 04
Randomized trial of the triple monoamine reuptake inhibitor NS 2330 (tesofensine) in early Parkinson's disease
- 05
Hauser RA, Salin L, Juhel N et al
Mov Disord / Mov Disord / Phase 2
NS 2330 did not provide significantly greater benefit than placebo in early Parkinson's disease.
- 06
NS 2330 did not provide significantly greater benefit than placebo in early Parkinson's disease
- 07
[The effect of tesofensine on body weight and body composition in obese subjects--secondary publication]
- 08
Nielsen AL, Larsen TM, Madsbad S et al
Ugeskr Laeger / Ugeskr Laeger / Phase 2
Tesofensine 0.5-1.0 mg produced weight loss 9-11% greater than placebo.
- 09
Tesofensine 0.5-1.0 mg produced weight loss 9-11% greater than placebo
- 10
Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial
Compound
Tesofensine compound data
- Formula
- C17H23Cl2NO
- Mol. weight
- 328.3 g/mol
- PubChem CID
- 11370864 ↗
- IUPAC
- (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane
FAQ
Tesofensine questions
What is TESOFENSINE?
Tesofensine is a triple monoamine reuptake inhibitor originally developed for Parkinson's and Alzheimer's disease, now researched primarily for its significant weight loss effects. It affects serotonin, norepinephrine, and dopamine.
How does TESOFENSINE work?
Inhibits reuptake of serotonin, norepinephrine, and dopamine, leading to reduced appetite, increased satiety, and potentially enhanced fat metabolism. Different mechanism than GLP-1 agonists.
Is TESOFENSINE legal to buy?
TESOFENSINE is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.
Where can I buy TESOFENSINE?
TESOFENSINE is available as a research compound from verified online vendors. Always verify third-party testing before purchasing.
What category does TESOFENSINE belong to?
TESOFENSINE is primarily classified as a weight loss & metabolic peptide. Peptides researched for their effects on weight management, fat metabolism, appetite regulation, and metabolic enhancement. This category includes GLP-1 agonists, dual/triple agonists, and other metabolic peptides.
What are the research benefits of TESOFENSINE?
TESOFENSINE has been studied for: Significant weight loss potential, Appetite suppression, Increased satiety, Potential cognitive benefits. Triple reuptake inhibitor; showed 10%+ weight loss in Phase 2 trials. Not yet FDA approved.
News
Tesofensine in the news
Athlete Advisory: What’s New on the 2025 WADA Prohibited List? - U.S. Anti Doping Agency
U.S. Anti Doping Agency / 24 months ago
Peptide Tesofensine - YouTube
YouTube / 50 months ago
It's Like Cocaine, But No Fun - Discover Magazine
Discover Magazine / 198 months ago
Tesofensine For Sale: 3 Legit Places To Buy Online - Mid-Day
Mid-Day / 28 months ago
News aggregated via Google News. Inclusion does not imply endorsement.
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