Rigin Peptide Therapy
Benefits, Side Effects, Cost & Protocols
Rigin (Lys-Thr-Thr-Lys) is a tetrapeptide immunomodulator that has been studied for its effects on immune system activation, T-cell maturation, and anti-inflammatory activity. In cosmetics, it is used for its skin-calming and anti-aging properties.
Clinically Reviewed
Reviewed by Alex Evans, PharmD, MBA · Updated May 2026
Evidence-Based
Sourced from FDA, PubMed & ClinicalTrials.gov · View sources
How Rigin Works
Suppresses interleukin-6 (IL-6) and other pro-inflammatory cytokine release from keratinocytes and immune cells, reducing chronic low-grade inflammation (inflammaging) in skin tissue.
Rigin FAQ
What is RIGIN?
Rigin (Palmitoyl Tetrapeptide-7) is a lipopeptide that reduces inflammation-driven skin aging by inhibiting IL-6 secretion, commonly paired with Pal-GHK in anti-aging formulations.
How does RIGIN work?
Suppresses interleukin-6 (IL-6) and other pro-inflammatory cytokine release from keratinocytes and immune cells, reducing chronic low-grade inflammation (inflammaging) in skin tissue.
Is RIGIN legal to buy?
RIGIN is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.
Where can I buy RIGIN?
RIGIN has mixed availability - it can be found through both compounding pharmacies (with prescription) and research suppliers.
What category does RIGIN belong to?
RIGIN is primarily classified as a skin, hair & cosmetic peptide. Peptides studied for cosmetic applications including skin rejuvenation, collagen production, tanning, hair growth, and anti-wrinkle effects.
What are the research benefits of RIGIN?
RIGIN has been studied for: Anti-inflammatory, Inflammaging reduction, IL-6 suppression, Skin aging prevention. Cosmetic lipopeptide; key ingredient in Matrixyl 3000 alongside Pal-GHK.
Key Studies
45 total on PubMed19 human trialsThe second life of antibodies
Biochemistry (Mosc)
IgG-derived peptide fragments exhibit immunostimulatory and neurotrophic activities
Palmitoyl-transferase 3 promotes mitochondrial antiviral signaling protein degradation by modulating its ubiquitination
Yi L, Song J, Zhang Z et al
In Vitro · Int J Biol Macromol
ZDHHC3 inhibits antiviral signaling by promoting MAVS degradation via ubiquitination
Antifungal Peptides with Unexpected Structure from a Library of Synthetic Analogs of Host-Defense Peptide Rigin
In Vitro · Int J Mol Sci
Rigin analogs with N-substitution and protected lateral chains show potent antifungal activity
Herpes Simplex Virus Type 2 Blocks IFN-β Production through the Viral UL24 N-Terminal Domain-Mediated Inhibition of IRF-3 Phosphorylation
Zhang B, Li Y, Yang P et al
In Vitro · Viruses
HSV-2 UL24 N-terminal domain inhibits IFN-β production by suppressing IRF-3 phosphorylation
Rigin Compound Data
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