Pnc-27
Peptide therapy: benefits, side effects, cost and protocols
PNC-27 is a synthetic peptide consisting of an HDM-2-binding domain attached to a membrane-active penetratin sequence. It has been studied for its ability to selectively target and destroy cancer cells by binding to HDM-2 overexpressed on tumor cell membranes, causing membrane lysis.
Sources: FDA / PubMed / ClinicalTrials.gov View
Spec sheet
- FDA status
- Research Only Not currently approved for human use in the US. Available as a research compound. Not eligible for compounding.
- Evidence
- Moderate Evidence
Mechanism
How Pnc-27 works
Contains HDM-2 binding domain that may selectively target cells with altered p53 expression.
Evidence
Key studies
25 papers on PubMed / 18 human trials
- 01
Death of preceding child and maternal healthcare services utilisation in Nigeria: investigation using lagged logit models
J Health Popul Nutr
- 02
Death of preceding child does not predict maternal healthcare service utilization in Nigeria after controlling for socioeconomic factors
- 03
A case-crossover analysis of out-of-hospital coronary deaths and air pollution in Rome, Italy
- 04
Forastiere F, Stafoggia M, Picciotto S et al
Am J Respir Crit Care Med
Air pollution exposure associated with 7.6% increased risk of out-of-hospital coronary death.
- 05
Air pollution exposure associated with 7.6% increased risk of out-of-hospital coronary death
- 06
Ex vivo Efficacy of Anti-Cancer Drug PNC-27 in the Treatment of Patient-Derived Epithelial Ovarian Cancer
- 07
Sarafraz-Yazdi E, Gorelick C, Wagreich AR et al
Case Series / Ann Clin Lab Sci
- 08
PNC-27 inhibits growth and is cytotoxic to patient-derived epithelial ovarian cancer cells in dose-dependent manner
- 09
Synergy between Paclitaxel and Anti-Cancer Peptide PNC-27 in the Treatment of Ovarian Cancer
- 10
Alagkiozidis I, Gorelick C, Shah T et al
Ann Clin Lab Sci / Ann Clin Lab Sci / Animal
FAQ
Pnc-27 questions
What is PNC-27?
PNC-27 is an experimental peptide researched for its potential selective effects on abnormal cells while sparing healthy cells.
How does PNC-27 work?
Contains HDM-2 binding domain that may selectively target cells with altered p53 expression.
Is PNC-27 legal to buy?
PNC-27 is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.
Where can I buy PNC-27?
PNC-27 is available as a research compound from verified online vendors. Always verify third-party testing before purchasing.
What category does PNC-27 belong to?
PNC-27 is primarily classified as a anti-aging & longevity peptide. Peptides studied for longevity, cellular senescence, telomere biology, and general anti-aging effects.
What are the research benefits of PNC-27?
PNC-27 has been studied for: Anti-cancer research, Selective cell targeting. Experimental; selective cell research.
News
Pnc-27 in the news
Terms of Service - Hellas Journal - Hellasjournal.com
Hellasjournal.com / 5 days ago
Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes - PNAS
PNAS / 203 months ago
FDA Cautions Against PNC-27 Use - Oncology Nursing News
Oncology Nursing News / 68 months ago
Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemia - Nature
Nature / 87 months ago
Unauthorized injectable peptides and their potential serious health risks - College of Physicians & Surgeons of Alberta | CPSA
College of Physicians & Surgeons of Alberta | CPSA / 6 months ago
News aggregated via Google News. Inclusion does not imply endorsement.
Related
Other Anti-Aging & Longevity peptides
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