Humanin Peptide Therapy
Benefits, Side Effects, Cost & Protocols
Humanin is a mitochondrial-derived peptide encoded by the 16S rRNA gene. It has cytoprotective properties against various cellular stresses and has been studied for neuroprotection, metabolic regulation, and anti-aging effects. It is one of the first mitochondrial-derived peptides discovered.
Clinically Reviewed
Reviewed by Alex Evans, PharmD, MBA · Updated May 2026
Evidence-Based
Sourced from FDA, PubMed & ClinicalTrials.gov · View sources
How Humanin Works
Acts through multiple pathways including STAT3 signaling, insulin/IGF-1 pathways, and FPRL receptors. Protects cells from oxidative stress and apoptosis, particularly in neurons.
Humanin FAQ
What is HUMANIN?
Humanin is a mitochondrial-derived peptide (MDP) discovered in 2001, researched for its neuroprotective and cytoprotective effects. It represents a class of peptides produced by mitochondrial DNA.
How does HUMANIN work?
Acts through multiple pathways including STAT3 signaling, insulin/IGF-1 pathways, and FPRL receptors. Protects cells from oxidative stress and apoptosis, particularly in neurons.
Is HUMANIN legal to buy?
HUMANIN is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.
Where can I buy HUMANIN?
HUMANIN is available as a research compound from verified online vendors. Always verify third-party testing before purchasing.
What category does HUMANIN belong to?
HUMANIN is primarily classified as a anti-aging & longevity peptide. Peptides studied for longevity, cellular senescence, telomere biology, and general anti-aging effects.
What are the research benefits of HUMANIN?
HUMANIN has been studied for: Neuroprotection, Mitochondrial support, Anti-apoptotic effects, Metabolic regulation, Longevity research. First identified mitochondrial-derived peptide; significant research in Alzheimer's and aging.
Key Studies
540 total on PubMed0Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease
Delgado-Peraza F, Nogueras-Ortiz C, Simonsen AH et al
Alzheimers Res Ther · Alzheimers Res TherRCT
Exercise increased neuroprotective proteins in neuron-derived extracellular vesicles, especially in APOE ε4 carriers.
Exercise increased neuroprotective proteins in neuron-derived extracellular vesicles, especially in APOE ε4 carriers
Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder
Goetzl EJ, Wolkowitz OM, Srihari VH et al
Mol Psychiatry · Mol Psychiatry
MDD patients showed significantly lower humanin/MOTS-c levels that normalized with SSRI response but not in non-responders.
MDD patients showed significantly lower humanin/MOTS-c levels that normalized with SSRI response but not in non-responders
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Lee C, Zeng J, Drew BG et al
Cell Metab · Cell MetabAnimal
MOTS-c treatment prevented age-dependent and diet-induced insulin resistance and obesity in mice
Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review)
Humanin Compound Data
Humanin News
Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull - Nature
Nature · 3 months ago
Humanin and Age-Related Diseases: A New Link? - Frontiers
Frontiers · 27 months ago
Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer - Nature
Nature · 72 months ago
Mediterranean Diet Linked to Higher Levels of Mitochondrial Microproteins - Conexiant
Conexiant · 1 month ago
The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change - Journal of Neuroscience
Journal of Neuroscience · 75 months ago
News aggregated via Google News. Inclusion does not imply endorsement.
Humanin Articles & Guides
In-depth articles about Humanin and related peptide therapies.
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Read article →Best Longevity Peptides for Healthspan Optimization: 7 Science-Backed Compounds Worth Knowing in 2026
Discover the top 7 longevity peptides for healthspan optimization in 2026. Evidence-based dosing, stacking protocols, and safety guidelines from clinical practice.
Read article →Thymosin Alpha 1 vs Thymosin Beta 4 for Longevity: Which Peptide Delivers Real Anti-Aging Results?
Compare thymosin alpha 1 vs thymosin beta 4 for longevity: immune restoration vs tissue repair, evidence, safety data, and whether combining them works.
Read article →FOXO4-DRI Senolytic Peptide: What the Latest Anti-Aging Research Reveals in 2026
FOXO4-DRI senolytic peptide selectively kills zombie cells to reverse aging. Explore 2026 research on vascular health, hormonal decline, and preclinical breakthroughs in anti-aging science.
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Related Peptides in Anti-Aging & Longevity
Epitalon
A synthetic tetrapeptide that activates telomerase, the enzyme responsible for maintaining telomere length. Studied for anti-aging and circadian rhythm regulation via melatonin pathways.
MOTS-C
A mitochondrial-derived peptide that regulates metabolic homeostasis. Acts as an exercise mimetic, improving insulin sensitivity and fat metabolism at the cellular level.
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