Skin, Hair & CosmeticAnecdotal

Vialox Peptide Therapy

Benefits, Side Effects, Cost & Protocols

Vialox peptide molecular structure diagram from PubChem

Vialox (pentapeptide-3) is a synthetic peptide that acts as a competitive antagonist of the acetylcholine receptor at the neuromuscular junction. It reduces muscle contraction and is used in cosmetics to smooth expression wrinkles.

ByChris Riley(CFA)&Alex Evans, PharmD, MBA(PharmD, MBA)|Updated July 3, 2026

Clinically Reviewed

Reviewed by Alex Evans, PharmD, MBA · Updated July 2026

Evidence-Based

Sourced from FDA, PubMed & ClinicalTrials.gov · View sources

FDA Status

Research Only Not currently approved for human use in the US. Available as a research compound. Not eligible for compounding.

Evidence

Anecdotal

How Vialox Works

Competitively antagonizes the acetylcholine receptor at the post-synaptic membrane, reducing muscle depolarization and contraction at the neuromuscular junction.

Vialox FAQ

What is VIALOX?

Vialox (Pentapeptide-3) is a synthetic cosmetic peptide that competitively inhibits acetylcholine binding at the neuromuscular junction, reducing muscle contraction and associated expression wrinkles.

How does VIALOX work?

Competitively antagonizes the acetylcholine receptor at the post-synaptic membrane, reducing muscle depolarization and contraction at the neuromuscular junction.

Is VIALOX legal to buy?

VIALOX is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.

Where can I buy VIALOX?

VIALOX has mixed availability - it can be found through both compounding pharmacies (with prescription) and research suppliers.

What category does VIALOX belong to?

VIALOX is primarily classified as a skin, hair & cosmetic peptide. Peptides studied for cosmetic applications including skin rejuvenation, collagen production, tanning, hair growth, and anti-wrinkle effects.

What are the research benefits of VIALOX?

VIALOX has been studied for: Muscle relaxation, Expression wrinkle reduction, Botox-like effects, Skin smoothing. Cosmetic peptide; nAChR antagonist. Similar mechanism to Syn-Ake but different target site.

Vialox Compound Data

Molecular Formula

C21H37N9O5

Molecular Weight

495.6 g/mol

IUPAC Name

(2S)-1-(2-aminoacetyl)-N-[(1S)-1-[(2S)-2-[[(1S)-2-amino-1-methyl-2-oxo-ethyl]carbamoyl]pyrrolidine-1-carbonyl]-4-guanidino-butyl]pyrrolidine-2-carboxamide

View full compound on PubChem

Vialox News

Quantum Chemical, Spectroscopic and In Silico (Molecular Docking, Molecular Dynamic and ADME) Studies on Anti-Aging Pentapeptide-3 (Vialox) - Wiley Online Library

Wiley Online Library · 11 months ago

Vialox Peptide: Potential in Biochemical and Cellular Research - CityWatch LA

CityWatch LA · 22 months ago

For Every Patient Their Own Drug - Nautilus | Science

Nautilus | Science · 1 month ago

Your Biological Clock Can be Measured With a Hair Sample - Nautilus | Science

Nautilus | Science · 3 months ago

There’s Never Been A Better Time To Be A Witch - ELLE Australia

ELLE Australia · 4 months ago

News aggregated via Google News. Inclusion does not imply endorsement.

Medical Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. Peptide therapies have not been evaluated by the FDA for most listed indications.All prices shown are estimates based on publicly available data and may not reflect current pricing — providers and brands set their own prices and can change them at any time. Always verify pricing directly with the provider before purchasing. Consult a licensed healthcare provider before starting any peptide protocol.

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