Tirzepatide
Peptide therapy: benefits, side effects, cost and protocols
C225H348N48O68
Tirzepatide is a dual GIP/GLP-1 receptor agonist used as an antidiabetic medication to treat type 2 diabetes and for weight loss. It is administered via subcutaneous injections and sold under the brand names Mounjaro for diabetes and Zepbound for weight loss and obstructive sleep apnea treatment.
Sources: FDA / PubMed / ClinicalTrials.gov View
Spec sheet
- Lowest listed
- $149/mo
- FDA status
- FDA-approved drug
- Evidence
- Strong Evidence
Price sheet
Tirzepatide prices, lowest first
22 listings, $149 to $1299 per month.
We may earn a commission at no extra cost to you. Disclosure
| Provider | Per month | Link |
|---|---|---|
Direct MedsOut of stock Tirzepatide Oral Drops / [unverifiable on public site Jul 2026] 503A CompoundedClinical | $149Lowest | Visit |
Ageless Rx Microdosing Tirzepatide / microdose weekly Research Use | $159 | Visit |
Clinic Secret Compounded Tirzepatide / $49/week 503A CompoundedClinical | $196 | Visit |
Calibrate Calibrate Tirzepatide / weekly injection ClinicalRx | $199 | Visit |
TeleHealth Med Compounded Tirzepatide 503A CompoundedClinical | $199 | Visit |
ShedRX Compounded Tirzepatide Injection 503A CompoundedClinical | $239 | Visit |
PeterMD Tirzepatide Injection / 2.5mg-15mg weekly ClinicalRx | $249 | Visit |
ReadyRx Compounded Tirzepatide 503A CompoundedClinical | $255 | Visit |
TrimRx Injectable Tirzepatide (GLP-1+GIP) 503A CompoundedClinical | $259 | Visit |
Hims Zepbound® Vial 503A CompoundedClinical | $299 | Visit |
Silhouette MD Tirzepatide Injection 503A CompoundedClinical | $299 | Visit |
Silhouette MD Tirzepatide Oral 503A CompoundedClinical | $325 | Visit |
TrimRxOut of stock Oral Tirzepatide (GLP-1+GIP) 503A CompoundedClinical | $330 | Visit |
Alpha HormonesOut of stock Tirzepatide / weekly injection ClinicalRx | $379 | Visit |
Prime Health Compounded Tirzepatide 503A CompoundedClinical | $399 | Visit |
Blue Sky MDOut of stock Tirzepatide Weight Loss / weekly injection Clinical | $399 | Visit |
Defy MedicalOut of stock Tirzepatide Injection / 2.5mg-15mg weekly ClinicalRx | $399 | Visit |
Willow Tirzepatide Injectable 503A CompoundedClinical | $399 | Visit |
Hone HealthOut of stock Tirzepatide Program / 2.5mg-15mg weekly ClinicalRx | $449 | Visit |
BodyLogicMDOut of stock Tirzepatide Program / weekly injection Research Use | $475 | Visit |
Direct MedsOut of stock Tirzepatide / weekly injection [unverifiable on public site Jul 2026] 503A CompoundedClinical | $497 | Visit |
VivioMDOut of stock GLP-1+GIP Injection (Tirzepatide) / [unverifiable on public site Jul 2026] FDA BrandClinical | $1299 | Visit |
Prices shown are estimates based on publicly available data and may not reflect current pricing. Actual costs may vary by location, insurance, dosage, and formulation. Always verify directly with the provider.
Mechanism
How Tirzepatide works
Dual incretin agonist targeting both GLP-1 and GIP receptors for enhanced metabolic effects beyond single-agonist peptides.
Evidence
Key studies
2,588 papers on PubMed / 1,412 human trials
- 01
Comparison of tirzepatide and dulaglutide on major adverse cardiovascular events in participants with type 2 diabetes and atherosclerotic cardiovascular disease: SURPASS-CVOT design and baseline characteristics
- 02
Nicholls SJ, Bhatt DL, Buse JB et al
Am Heart J / Am Heart J / Phase 3
- 03
SURPASS-CVOT comparing tirzepatide vs dulaglutide for cardiovascular outcomes in type 2 diabetes (ongoing trial)
- 04
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes
- 05
Nicholls SJ, Pavo I, Bhatt DL et al
N Engl J Med / Phase 3
- 06
Tirzepatide noninferior to dulaglutide for cardiovascular outcomes in type 2 diabetes with atherosclerotic disease
- 07
Tirzepatide Once Weekly for the Treatment of Obesity
- 08
Jastreboff AM, Aronne LJ, Ahmad NN et al
N Engl J Med / Phase 3
Tirzepatide 5-15mg produced 15-20.9% weight loss with 85-91% achieving ≥5% weight reduction.
- 09
Tirzepatide 5-15mg produced 15-20.9% weight loss with 85-91% achieving ≥5% weight reduction
- 10
Effects of tirzepatide versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: post-hoc analysis of an open-label, randomised, phase 3 trial
Compound
Tirzepatide compound data
- Formula
- C225H348N48O68
- Mol. weight
- 4813 g/mol
- PubChem CID
- 166567236 ↗
- IUPAC
- 20-[[(1S)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-methyl-propanoyl]amino]-4-carboxy-butanoyl]amino]acetyl]amino]-3-hydroxy-butanoyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]amino]-3-carboxy-propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxy-propanoyl]amino]-3-methyl-pentanoyl]amino]-2-methyl-propanoyl]amino]-4-methyl-pentanoyl]amino]-3-carboxy-propanoyl]amino]hexanoyl]amino]-3-methyl-pentanoyl]amino]propanoyl]amino]-5-oxo-pentanoyl]amino]-6-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-4-amino-1-[[(1S)-2-[[(1S)-1-[[(1S,2S)-1-[[(1S)-2-[[2-[[2-[(2S)-2-[[(1S)-2-[[(1S)-2-[[2-[[(1S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[[(1S)-2-amino-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl]amino]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]pyrrolidin-1-yl]-2-oxo-ethyl]amino]-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]carbamoyl]-3-methyl-butyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-4-oxo-butyl]carbamoyl]-2-methyl-propyl]amino]-1-benzyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-6-oxo-hexyl]amino]-2-oxo-ethoxy]ethoxy]ethylamino]-2-oxo-ethoxy]ethoxy]ethylamino]-1-carboxy-4-oxo-butyl]amino]-20-oxo-icosanoic acid
FAQ
Tirzepatide questions
What is TIRZEPATIDE?
Tirzepatide is a dual GLP-1/GIP agonist that has shown exceptional weight loss results in clinical trials. Following FDA compounding restrictions similar to semaglutide, research vendor demand has surged significantly.
How does TIRZEPATIDE work?
Dual incretin agonist targeting both GLP-1 and GIP receptors for enhanced metabolic effects beyond single-agonist peptides.
Is TIRZEPATIDE legal to buy?
TIRZEPATIDE requires a prescription from a licensed healthcare provider. It is legal to purchase with a valid prescription from authorized pharmacies.
Where can I buy TIRZEPATIDE?
TIRZEPATIDE is available by prescription through compounding pharmacies and telehealth providers. Browse our verified provider directory to find trusted sources.
What category does TIRZEPATIDE belong to?
TIRZEPATIDE is primarily classified as a weight loss & metabolic peptide. Peptides researched for their effects on weight management, fat metabolism, appetite regulation, and metabolic enhancement. This category includes GLP-1 agonists, dual/triple agonists, and other metabolic peptides.
What are the research benefits of TIRZEPATIDE?
TIRZEPATIDE has been studied for: Significant weight loss, Dual receptor activation, Glycemic control, Appetite suppression. Dual agonist; massive demand following compounding restrictions.
News
Tirzepatide in the news
Peptide Sciences Tirzepatide in 2026: What Happened to the Original Listings, and What Researchers Should Know About EU Peptide Sciences - Inter Press Service
Inter Press Service / today
Volta Peptides Wins Research Peptide Supplier of the Year 2026 Award from Peptide Atlas - USA Today
USA Today / today
Unregulated Peptides Lack Purity Testing: Catherine Varney, DO - AJMC
AJMC / 5 days ago
The Precision Peptide Company Inc. Announces Development of Needle-Free Tirzepatide Transdermal Patch - Yahoo Finance
Yahoo Finance / 1 month ago
Semaglutide and Tirzepatide API CDMO Market Size, 2035 Report - Global Market Insights Inc.
Global Market Insights Inc. / 2 months ago
News aggregated via Google News. Inclusion does not imply endorsement.
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