Growth Hormone SecretionStrong Evidence

Tesamorelin Peptide Therapy

Benefits, Side Effects, Cost & Protocols

Tesamorelin injection vial product photo

Tesamorelin peptide molecular structure diagram from PubChem

Tesamorelin is a synthetic form of growth-hormone-releasing hormone (GHRH) approved for the treatment of HIV-associated lipodystrophy. It is a synthetic peptide consisting of all 44 amino acids of human GHRH with the addition of a trans-3-hexenoic acid group.

ByChris Riley(CFA)&Alex Evans, PharmD, MBA(PharmD, MBA)|Updated May 19, 2026

Clinically Reviewed

Reviewed by Alex Evans, PharmD, MBA · Updated May 2026

Evidence-Based

Sourced from FDA, PubMed & ClinicalTrials.gov · View sources

FDA Status

FDA-approved drug

Evidence

Strong Evidence

Compare Tesamorelin Prices

1 provider offering Tesamorelin — sorted lowest price first

Defy Medical

Tesamorelin Injection· 2mg daily

ClinicalRx

$350

/month

Get Started

Prices shown are estimates based on publicly available data and may not reflect current pricing. Actual costs may vary by location, insurance, dosage, and formulation. Always verify directly with the provider.

Who Is Tesamorelin Best For?

Visceral fat reductionBody compositionGH stimulationMetabolic health

How Tesamorelin Works

GHRH analog that stimulates natural GH release with particular efficacy for reducing abdominal/visceral fat.

Tesamorelin FAQ

What is TESAMORELIN?

Tesamorelin is a GHRH analog specifically researched and approved for reducing visceral adipose tissue. It's available through compounding pharmacies and has a strong track record for body composition improvement.

How does TESAMORELIN work?

GHRH analog that stimulates natural GH release with particular efficacy for reducing abdominal/visceral fat.

Is TESAMORELIN legal to buy?

TESAMORELIN requires a prescription from a licensed healthcare provider. It is legal to purchase with a valid prescription from authorized pharmacies.

Where can I buy TESAMORELIN?

TESAMORELIN is available by prescription through compounding pharmacies and telehealth providers. Browse our verified provider directory to find trusted sources.

What category does TESAMORELIN belong to?

TESAMORELIN is primarily classified as a growth hormone secretion peptide. Peptides that stimulate or support growth hormone release, including GHRH analogs, GHRPs, and direct GH compounds for muscle, recovery, and anti-aging research.

What are the research benefits of TESAMORELIN?

TESAMORELIN has been studied for: Visceral fat reduction, Body composition, GH stimulation, Metabolic health. Body composition focus; excellent for visceral fat research.

Key Studies

113 total on PubMed92 human trials

Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV

Fourman LT, Czerwonka N, Feldpausch MN et al

AIDSPhase 3

VAT responders to tesamorelin showed greater reductions in liver enzymes ALT and AST.

VAT responders to tesamorelin showed greater reductions in liver enzymes ALT and AST

Predictors of Treatment Response to Tesamorelin, a Growth Hormone-Releasing Factor Analog, in HIV-Infected Patients with Excess Abdominal Fat

Mangili A, Falutz J, Mamputu JC et al

PLoS OnePhase 3

Metabolic syndrome and elevated triglycerides predicted superior VAT reduction response to tesamorelin.

Metabolic syndrome and elevated triglycerides predicted superior VAT reduction response to tesamorelin

Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data

Falutz J, Mamputu JC, Potvin D et al

J Clin Endocrinol MetabPhase 3

Tesamorelin reduced VAT by 24% at 26 weeks with sustained benefits at 52 weeks and improved lipid profile.

Tesamorelin reduced VAT by 24% at 26 weeks with sustained benefits at 52 weeks and improved lipid profile

Effects of tesamorelin on inflammatory markers in HIV patients with excess abdominal fat: relationship with visceral adipose reduction

Tesamorelin Compound Data

Molecular Formula

C221H366N72O67S

Molecular Weight

5136 g/mol

IUPAC Name

(4S)-4-[[2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-2-[[(2S)-2-[[(E)-hex-3-enoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]-3-methyl-pentanoyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]-4-oxo-butanoyl]amino]-3-hydroxy-propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-guanidino-pentanoyl]amino]hexanoyl]amino]-3-methyl-butanoyl]amino]-4-methyl-pentanoyl]amino]acetyl]amino]-5-oxo-pentanoyl]amino]-4-methyl-pentanoyl]amino]-3-hydroxy-propanoyl]amino]propanoyl]amino]-5-guanidino-pentanoyl]amino]hexanoyl]amino]-4-methyl-pentanoyl]amino]-4-methyl-pentanoyl]amino]-5-oxo-pentanoyl]amino]-3-carboxy-propanoyl]amino]-3-methyl-pentanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-3-hydroxy-propanoyl]amino]-5-guanidino-pentanoyl]amino]-5-oxo-pentanoyl]amino]-5-oxo-pentanoyl]amino]acetyl]amino]-5-[[(1S)-2-[[(1S)-3-amino-1-[[(1S)-4-amino-1-[[(1S)-1-[[(1S)-1-[[2-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-1-carbamoyl-3-methyl-butyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-3-carboxy-propyl]carbamoyl]-4-oxo-butyl]carbamoyl]-3-oxo-propyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-5-oxo-pentanoic acid

View full compound on PubChem

Tesamorelin News

Peptides Promise Health Benefits, But Do They Actually Work? | Health Matters | NYP - NewYork-Presbyterian

NewYork-Presbyterian · 4 days ago

The peptide problem: Hype is outrunning the evidence - The Conversation

The Conversation · 12 days ago

Tesamorelin studies show targeted visceral fat loss - MSN

MSN · 7 days ago

People are injecting peptides for weight loss and longevity. Doctors are alarmed at the side effects. - Business Insider

Business Insider · 23 days ago

The Peptide Craze - Ground Truths | Eric Topol

Ground Truths | Eric Topol · 10 months ago

News aggregated via Google News. Inclusion does not imply endorsement.

Medical Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. Peptide therapies have not been evaluated by the FDA for most listed indications.All prices shown are estimates based on publicly available data and may not reflect current pricing — providers and brands set their own prices and can change them at any time. Always verify pricing directly with the provider before purchasing. Consult a licensed healthcare provider before starting any peptide protocol.

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