Growth Hormone SecretionHigh evidence

Tesamorelin

Peptide therapy: benefits, side effects, cost and protocols

C₂₂₁H₃₆₆N₇₂O₆₇S

5,136 g/mol / CID 16137828

Tesamorelin is a synthetic form of growth-hormone-releasing hormone (GHRH) approved for the treatment of HIV-associated lipodystrophy. It is a synthetic peptide consisting of all 44 amino acids of human GHRH with the addition of a trans-3-hexenoic acid group.

ByChris Riley(CFA)|Updated October 10, 2026

Sources: FDA / PubMed / ClinicalTrials.gov View

Spec sheet

Lowest listed: $350/mo
FDA status: FDA-approved drug
Evidence: Strong Evidence

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Price sheet

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Tesamorelin listed prices by provider
Provider	Per month	Link
Defy Medical Tesamorelin Injection / 2mg daily ClinicalRx	$350	Visit

Prices shown are estimates based on publicly available data and may not reflect current pricing. Actual costs may vary by location, insurance, dosage, and formulation. Always verify directly with the provider.

Who it's for

Who Tesamorelin is usually considered for

Visceral fat reduction
Body composition
GH stimulation
Metabolic health

Mechanism

How Tesamorelin works

GHRH analog that stimulates natural GH release with particular efficacy for reducing abdominal/visceral fat.

Evidence

Key studies

121 papers on PubMed / 100 human trials

01
Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV
02
Fourman LT, Czerwonka N, Feldpausch MN et al
AIDS / Phase 3
VAT responders to tesamorelin showed greater reductions in liver enzymes ALT and AST.
03
VAT responders to tesamorelin showed greater reductions in liver enzymes ALT and AST
04
Predictors of Treatment Response to Tesamorelin, a Growth Hormone-Releasing Factor Analog, in HIV-Infected Patients with Excess Abdominal Fat
05
Mangili A, Falutz J, Mamputu JC et al
PLoS One / Phase 3
Metabolic syndrome and elevated triglycerides predicted superior VAT reduction response to tesamorelin.
06
Metabolic syndrome and elevated triglycerides predicted superior VAT reduction response to tesamorelin
07
Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data
08
Falutz J, Mamputu JC, Potvin D et al
J Clin Endocrinol Metab / Phase 3
Tesamorelin reduced VAT by 24% at 26 weeks with sustained benefits at 52 weeks and improved lipid profile.
09
Tesamorelin reduced VAT by 24% at 26 weeks with sustained benefits at 52 weeks and improved lipid profile
10
Effects of tesamorelin on inflammatory markers in HIV patients with excess abdominal fat: relationship with visceral adipose reduction

Compound

Tesamorelin compound data

Formula: C221H366N72O67S
Mol. weight: 5136 g/mol
PubChem CID: 16137828 ↗
IUPAC: (4S)-4-[[2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-2-[[(2S)-2-[[(E)-hex-3-enoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]-3-methyl-pentanoyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]-4-oxo-butanoyl]amino]-3-hydroxy-propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-guanidino-pentanoyl]amino]hexanoyl]amino]-3-methyl-butanoyl]amino]-4-methyl-pentanoyl]amino]acetyl]amino]-5-oxo-pentanoyl]amino]-4-methyl-pentanoyl]amino]-3-hydroxy-propanoyl]amino]propanoyl]amino]-5-guanidino-pentanoyl]amino]hexanoyl]amino]-4-methyl-pentanoyl]amino]-4-methyl-pentanoyl]amino]-5-oxo-pentanoyl]amino]-3-carboxy-propanoyl]amino]-3-methyl-pentanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-3-hydroxy-propanoyl]amino]-5-guanidino-pentanoyl]amino]-5-oxo-pentanoyl]amino]-5-oxo-pentanoyl]amino]acetyl]amino]-5-[[(1S)-2-[[(1S)-3-amino-1-[[(1S)-4-amino-1-[[(1S)-1-[[(1S)-1-[[2-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-1-carbamoyl-3-methyl-butyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-3-carboxy-propyl]carbamoyl]-4-oxo-butyl]carbamoyl]-3-oxo-propyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-5-oxo-pentanoic acid

FAQ

Tesamorelin questions

What is TESAMORELIN?

Tesamorelin is a GHRH analog specifically researched and approved for reducing visceral adipose tissue. It's available through compounding pharmacies and has a strong track record for body composition improvement.

How does TESAMORELIN work?

GHRH analog that stimulates natural GH release with particular efficacy for reducing abdominal/visceral fat.

Is TESAMORELIN legal to buy?

TESAMORELIN requires a prescription from a licensed healthcare provider. It is legal to purchase with a valid prescription from authorized pharmacies.

Where can I buy TESAMORELIN?

TESAMORELIN is available by prescription through compounding pharmacies and telehealth providers. Browse our verified provider directory to find trusted sources.

What category does TESAMORELIN belong to?

TESAMORELIN is primarily classified as a growth hormone secretion peptide. Peptides that stimulate or support growth hormone release, including GHRH analogs, GHRPs, and direct GH compounds for muscle, recovery, and anti-aging research.

What are the research benefits of TESAMORELIN?

TESAMORELIN has been studied for: Visceral fat reduction, Body composition, GH stimulation, Metabolic health. Body composition focus; excellent for visceral fat research.

News

Tesamorelin in the news

News aggregated via Google News. Inclusion does not imply endorsement.

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