Tissue Repair & HealingStrong Evidence

TB-500 Peptide Therapy

Benefits, Side Effects, Cost & Protocols

TB-500 peptide molecular structure diagram from PubChem

Thymosin beta-4 (TB-500) is a protein encoded by the TMSB4X gene in humans. It is a 43-amino acid peptide that has been studied for its role in tissue repair, wound healing, and anti-inflammatory activity. The recommended INN is timbetasin.

ByChris Riley(CFA)&Alex Evans, PharmD, MBA(PharmD, MBA)|Updated May 19, 2026

Clinically Reviewed

Reviewed by Alex Evans, PharmD, MBA · Updated May 2026

Evidence-Based

Sourced from FDA, PubMed & ClinicalTrials.gov · View sources

FDA Status

Banned from Compounding March 2024 Not eligible for compounding. Thymosin Beta-4 fragment removed from nomination list.

Evidence

Strong Evidence

Compare TB-500 Prices

1 provider offering TB-500 — sorted lowest price first

Defy Medical

TB-500 Injection· 750mcg 2x/week

ClinicalRx

$165

/month

Get Started

Prices shown are estimates based on publicly available data and may not reflect current pricing. Actual costs may vary by location, insurance, dosage, and formulation. Always verify directly with the provider.

Who Is TB-500 Best For?

Tissue repairFlexibility improvementWound healingSystemic recovery

How TB-500 Works

Regulates actin, a cell-building protein, promoting cell migration, blood vessel growth, and tissue regeneration throughout the body.

TB-500 FAQ

What is TB-500?

TB-500 is a synthetic version of the naturally occurring Thymosin Beta-4, one of the most popular peptides for tissue repair and recovery research.

How does TB-500 work?

Regulates actin, a cell-building protein, promoting cell migration, blood vessel growth, and tissue regeneration throughout the body.

Is TB-500 legal to buy?

TB-500 is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.

Where can I buy TB-500?

TB-500 has mixed availability - it can be found through both compounding pharmacies (with prescription) and research suppliers.

What category does TB-500 belong to?

TB-500 is primarily classified as a tissue repair & healing peptide. Peptides studied for their potential in wound healing, tendon/ligament repair, gut healing, and general tissue regeneration.

What are the research benefits of TB-500?

TB-500 has been studied for: Tissue repair, Flexibility improvement, Wound healing, Systemic recovery. Actin regulation; systemic healing effects.

Key Studies

16 total on PubMed11 human trials

Thymosin β4 Promotes Dermal Healing

Vitam Horm · Vitam HormPhase 2

Thymosin beta 4 accelerated dermal wound repair in patients with pressure ulcers and chronic wounds

Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain

Case Series · Altern Ther Health Med

87.5% of patients showed knee pain relief with BPC-157 injection alone or combined with thymosin beta-4.

87.5% of patients showed knee pain relief with BPC-157 injection alone or combined with thymosin beta-4

Identification of glutamine as a potential therapeutic target in dry eye disease

Chen X, Zhang C, Peng F et al

Signal Transduct Target Ther · Signal Transduct Target TherAnimal

Glutamine metabolism via GLS1 inhibition reduces inflammation and apoptosis in dry eye disease

Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies

Bock-Marquette I, Maar K, Maar S et al

Int Immunopharmacol · Int ImmunopharmacolAnimal

Thymosin beta-4 promotes cardiac cell survival and regeneration by reactivating embryonic programs in adult hearts

TB-500 Compound Data

Molecular Formula

C212H350N56O78S

Molecular Weight

4963 g/mol

IUPAC Name

4-[[2-[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[1-[2-[[1-[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[2-[[2-[[2-[[1-[2-[[2-[(2-acetamido-3-hydroxy-propanoyl)amino]-3-carboxy-propanoyl]amino]-6-amino-hexanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxy-propanoyl]amino]-4-methylsulfanyl-butanoyl]amino]propanoylamino]-4-carboxy-butanoyl]amino]-3-methyl-pentanoyl]amino]-4-carboxy-butanoyl]amino]-6-amino-hexanoyl]amino]-3-phenyl-propanoyl]amino]-3-carboxy-propanoyl]amino]-6-amino-hexanoyl]amino]-3-hydroxy-propanoyl]amino]-6-amino-hexanoyl]amino]-4-methyl-pentanoyl]amino]-6-amino-hexanoyl]amino]-6-amino-hexanoyl]amino]-3-hydroxy-butanoyl]amino]-4-carboxy-butanoyl]amino]-3-hydroxy-butanoyl]amino]-5-amino-5-oxo-pentanoyl]amino]-4-carboxy-butanoyl]amino]-6-amino-hexanoyl]amino]-4-amino-4-oxo-butanoyl]pyrrolidine-2-carbonyl]amino]-4-methyl-pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxy-propanoyl]amino]-6-amino-hexanoyl]amino]-4-carboxy-butanoyl]amino]-3-hydroxy-butanoyl]amino]-3-methyl-pentanoyl]amino]-4-carboxy-butanoyl]amino]-5-amino-5-oxo-pentanoyl]amino]-4-carboxy-butanoyl]amino]-6-amino-hexanoyl]amino]-5-amino-5-oxo-pentanoyl]amino]propanoylamino]acetyl]amino]-5-[(1-carboxy-2-hydroxy-ethyl)amino]-5-oxo-pentanoic acid

View full compound on PubChem

TB-500 News

Can peptide injections help people recover from injuries? Here’s what you need to know - The Conversation

The Conversation · 11 days ago

TB-500 and BPC-157: Core Peptides Highlights Peptide Synergy for Recovery, Regeneration, and Cellular Support - Yahoo Finance

Yahoo Finance · 6 months ago

TB 500 for male enhancement - Portal CNJ

Portal CNJ · 8 days ago

Peptides, explained: Answers to your top questions - Your Local Epidemiologist

Your Local Epidemiologist · 26 days ago

The peptide problem: Hype is outrunning the evidence - The Conversation

The Conversation · 12 days ago

News aggregated via Google News. Inclusion does not imply endorsement.

Medical Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. Peptide therapies have not been evaluated by the FDA for most listed indications.All prices shown are estimates based on publicly available data and may not reflect current pricing — providers and brands set their own prices and can change them at any time. Always verify pricing directly with the provider before purchasing. Consult a licensed healthcare provider before starting any peptide protocol.

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