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Cognitive EnhancementHigh evidence

Semax

Peptide therapy: benefits, side effects, cost and protocols

7 aa / 813.9 g/mol / CID 9811102
MEHFPGP

Semax is a synthetic heptapeptide nootropic developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is used in Eastern Europe for brain trauma treatment and for its claimed neuroprotective, nootropic, and neurorestorative effects.

ByChris Riley(CFA)|Updated

Sources: FDA / PubMed / ClinicalTrials.gov View

Spec sheet

FDA status
Banned from Compounding March 2024 Not eligible for compounding. Synthetic ACTH fragment not approved for human use in the US.
Evidence
Strong Evidence
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Who it's for

Who Semax is usually considered for

  • Cognitive enhancement
  • Neuroprotection
  • Memory improvement
  • Focus
  • Phase 4

Mechanism

How Semax works

ACTH (4-10) analog that may enhance BDNF levels and modulate neurotransmitter systems without hormonal effects.

Evidence

Key studies

232 papers on PubMed / 52 human trials

  1. 01

    [Results of the application of complex physiotherapeutic neurostimulation in optical neuropathies of various genesis]

  2. 02

    Dragon AK, Korchazhkina NB, Sheludchenko VM et al

    Vopr Kurortol Fizioter Lech Fiz Kult / Vopr Kurortol Fizioter Lech Fiz Kult / RCT

    Complex neurostimulation with Semax achieved 83-94% efficacy in improving visual field and light sensitivity in vascular optic neuropathy.

  3. 03

    Complex neurostimulation with Semax achieved 83-94% efficacy in improving visual field and light sensitivity in vascular optic neuropathy

  4. 04

    Functional Connectomic Approach to Studying Selank and Semax Effects

  5. 05

    Panikratova YR, Lebedeva IS, Sokolov OY et al

    Dokl Biol Sci / Dokl Biol Sci / RCT

  6. 06

    Selank and Semax produce distinct functional connectivity changes in amygdala and prefrontal regions

  7. 07

    Effects of Semax on the Default Mode Network of the Brain

  8. 08

    Lebedeva IS, Panikratova YR, Sokolov OY et al

    Bull Exp Biol Med / Bull Exp Biol Med / RCT

  9. 09

    Semax increased default mode network volume in medial frontal cortex compared to placebo on fMRI

  10. 10

    Sigmoidal maximal effect modeling of low-density lipoprotein cholesterol concentration and annual incidence of coronary heart disease events in secondary prevention trials

    Pharmacotherapy

Compound

Semax compound data

Formula
C37H51N9O10S
Mol. weight
813.9 g/mol
PubChem CID
9811102 ↗
IUPAC
(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanyl-butanoyl]amino]-4-carboxy-butanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenyl-propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid

FAQ

Semax questions

What is SEMAX?

Semax is a synthetic peptide based on ACTH (adrenocorticotropic hormone) fragment, developed in Russia and extensively researched for cognitive enhancement and neuroprotection.

How does SEMAX work?

ACTH (4-10) analog that may enhance BDNF levels and modulate neurotransmitter systems without hormonal effects.

Is SEMAX legal to buy?

SEMAX is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.

Where can I buy SEMAX?

SEMAX is available as a research compound from verified online vendors. Always verify third-party testing before purchasing.

What category does SEMAX belong to?

SEMAX is primarily classified as a cognitive enhancement peptide. Nootropic peptides researched for cognitive function, memory, focus, neuroprotection, and neurogenesis.

What are the research benefits of SEMAX?

SEMAX has been studied for: Cognitive enhancement, Neuroprotection, Memory improvement, Focus. ACTH analog; established nootropic peptide.

News

Semax in the news

News aggregated via Google News. Inclusion does not imply endorsement.

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