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Semaglutide peptide therapy
Weight Loss & MetabolicStrong Evidence

Semaglutide Peptide Therapy

Benefits, Side Effects, Cost & Protocols

Semaglutide injection vial product photoSemaglutide peptide molecular structure diagram from PubChem

Semaglutide is an anti-diabetic medication used for the treatment of type 2 diabetes, and an anti-obesity medication used for long-term weight management and to reduce the risk of major adverse cardiovascular events. It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain. It can be administered by subcutaneous injection or taken orally. Sold under the brand names Ozempic, Rybelsus, and Wegovy.

ByChris Riley(CFA)&Alex Evans, PharmD, MBA(PharmD, MBA)|Updated

Clinically Reviewed

Reviewed by Alex Evans, PharmD, MBA · Updated June 2026

Evidence-Based

Sourced from FDA, PubMed & ClinicalTrials.gov · View sources

FDA Status
FDA-approved drug
Evidence
Strong Evidence
Category
Weight Loss & Metabolic

Compare Semaglutide Prices

33 providers offering Semaglutide — sorted lowest price first

We may earn a commission at no extra cost to you. Disclosure

Lowest Price
Direct Meds
Semaglutide· weekly injection
503A CompoundedClinical
$147
/month
Get Started
TeleHealth Med
Compounded Semaglutide
503A CompoundedClinical
$147
/month
Get Started
Hims
Wegovy® Pill
503A CompoundedClinical
$149
/month
Get Started
Direct Meds
Semaglutide Oral Drops
503A CompoundedClinical
$149
/month
Get Started
Silhouette MD
Semaglutide Injection
503A CompoundedClinical
$149
/month
Get Started
TrimRx
Injectable Semaglutide
503A CompoundedClinical
$179
/month
Get Started
TrimRx
Oral Semaglutide
503A CompoundedClinical
$179
/month
Get Started
Clinic Secret
Compounded Semaglutide· $49/week
503A CompoundedClinical
$196
/month
Get Started
PeterMD
Semaglutide Injection· 0.25mg-2.4mg weekly
ClinicalRx
$197
/month
Get Started
Hims
Ozempic®
503A CompoundedClinical
$199
/month
Get Started
Hims
Wegovy® Pen
503A CompoundedClinical
$199
/month
Get Started
ShedRX
GLP-1 Lozenges
503A CompoundedClinical
$199
/month
Get Started
ShedRX
Compounded Semaglutide Injection
503A CompoundedClinical
$199
/month
Get Started
BrightMeds
Semaglutide· weekly injection
ClinicalRx
$215
/month
Get Started
BreezeMeds
Semaglutide· weekly injection
503A CompoundedClinical
$225
/month
Get Started
ShedRX
GLP-1 Liquid Drops
503A CompoundedClinical
$229
/month
Get Started
Alpha Hormones
Semaglutide· weekly injection
ClinicalRx
$249
/month
Get Started
Blue Sky MD
Semaglutide Weight Loss· weekly injection
Clinical
$249
/month
Get Started
Better Life Medical
Semaglutide· weekly injection
Clinical
$259
/month
Get Started
Silhouette MD
Semaglutide Oral
503A CompoundedClinical
$263
/month
Get Started
Belle Health
Semaglutide· weekly injection
ClinicalRx
$275
/month
Get Started
Defy Medical
Semaglutide Injection· 0.25mg-2.4mg weekly
ClinicalRx
$289
/month
Get Started
Prime Health
Compounded Semaglutide
503A CompoundedClinical
$299
/month
Get Started
Calibrate
Calibrate Semaglutide· weekly injection
ClinicalRx
$299
/month
Get Started
ShedRX
Oral Semaglutide Tablets
503A CompoundedClinical
$299
/month
Get Started
ReadyRx
Compounded Semaglutide
503A CompoundedClinical
$299
/month
Get Started
Willow
Semaglutide Injectable
503A CompoundedClinical
$299
/month
Get Started
Willow
Semaglutide Oral
503A CompoundedClinical
$299
/month
Get Started
VivioMDOut of Stock
GLP-1 Tablets (Semaglutide)
FDA BrandClinical
$299
/month
Get Started
Hone Health
Semaglutide Program· 0.25mg-2.4mg weekly
ClinicalRx
$299
/month
Get Started
BodyLogicMD
Semaglutide Program· weekly injection
Research Use
$325
/month
Get Started
Ageless Rx
Semaglutide· weekly injection
Research Use
$349
/month
Get Started
VivioMD
GLP-1 Injection (Semaglutide)
FDA BrandClinical
$398
/month
Get Started

Prices shown are estimates based on publicly available data and may not reflect current pricing. Actual costs may vary by location, insurance, dosage, and formulation. Always verify directly with the provider.

Who Is Semaglutide Best For?

Weight lossAppetite suppressionGlycemic controlMetabolic health

How Semaglutide Works

GLP-1 receptor agonist that reduces appetite, slows gastric emptying, and improves insulin sensitivity for weight management.

Semaglutide FAQ

What is SEMAGLUTIDE?

Semaglutide is the GLP-1 agonist that revolutionized weight loss treatment. Following FDA resolution of shortages in 2025 and subsequent compounding restrictions, research-grade semaglutide has seen significant demand increases.

How does SEMAGLUTIDE work?

GLP-1 receptor agonist that reduces appetite, slows gastric emptying, and improves insulin sensitivity for weight management.

Is SEMAGLUTIDE legal to buy?

SEMAGLUTIDE requires a prescription from a licensed healthcare provider. It is legal to purchase with a valid prescription from authorized pharmacies.

Where can I buy SEMAGLUTIDE?

SEMAGLUTIDE is available by prescription through compounding pharmacies and telehealth providers. Browse our verified provider directory to find trusted sources.

What category does SEMAGLUTIDE belong to?

SEMAGLUTIDE is primarily classified as a weight loss & metabolic peptide. Peptides researched for their effects on weight management, fat metabolism, appetite regulation, and metabolic enhancement. This category includes GLP-1 agonists, dual/triple agonists, and other metabolic peptides.

What are the research benefits of SEMAGLUTIDE?

SEMAGLUTIDE has been studied for: Weight loss, Appetite suppression, Glycemic control, Metabolic health. GLP-1 classic; restricted compounding has increased research vendor demand.

Key Studies

4,895 total on PubMed2,823 human trials

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes

Lincoff AM, Brown-Frandsen K, Colhoun HM et al

N Engl J MedPhase 3

Semaglutide reduced cardiovascular events in obese patients with cardiovascular disease but without diabetes

Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes

McGuire DK, Marx N, Mulvagh SL et al

N Engl J MedPhase 3

Oral semaglutide reduced major adverse cardiovascular events vs placebo in high-risk type 2 diabetes

Effects of oral semaglutide on cardiovascular outcomes in individuals with type 2 diabetes and established atherosclerotic cardiovascular disease and/or chronic kidney disease: Design and baseline characteristics of SOUL, a randomized trial

McGuire DK, Busui RP, Deanfield J et al

Diabetes Obes Metab · Diabetes Obes MetabPhase 3

SOUL trial design for assessing oral semaglutide effects on cardiovascular outcomes in type 2 diabetes with atherosclerotic disease and/or chronic kidney disease

Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes

Semaglutide Compound Data

Semaglutide peptide chemical structure and molecular formula from PubChem
Molecular Formula
C187H291N45O59
Molecular Weight
4114 g/mol
IUPAC Name
18-[[(1R)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-2-methyl-propanoyl]amino]-4-carboxy-butanoyl]amino]acetyl]amino]-3-hydroxy-butanoyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]amino]-3-carboxy-propanoyl]amino]-3-methyl-butanoyl]amino]-3-hydroxy-propanoyl]amino]-3-hydroxy-propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methyl-pentanoyl]amino]-4-carboxy-butanoyl]amino]acetyl]amino]-5-oxo-pentanoyl]amino]propanoyl]amino]propanoyl]amino]-6-[[(1S)-1-[[(1S)-1-benzyl-2-[[(1S,2S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[2-[[(1S)-1-(carboxymethylcarbamoyl)-4-guanidino-butyl]amino]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-methyl-butyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]amino]-2-oxo-ethyl]carbamoyl]-3-carboxy-propyl]amino]-6-oxo-hexyl]amino]-2-oxo-ethoxy]ethoxy]ethylamino]-2-oxo-ethoxy]ethoxy]ethylamino]-1-carboxy-4-oxo-butyl]amino]-18-oxo-octadecanoic acid
View full compound on PubChem

Semaglutide News

The Science Behind the Quest for a Non-Peptide Oral Weight Loss Drug A - American Council on Science and Health

American Council on Science and Health · 4 days ago

Optimised semaglutide formulation could advance peptide-based oral delivery - European Pharmaceutical Review

European Pharmaceutical Review · 16 days ago

GLP-1 Weight-Loss Pills: What You Need to Know - Yale Medicine

Yale Medicine · 1 month ago

Fibrillar and Micellar Aggregation of Semaglutide and Formation of a Chiral-Imprinted Glass - ACS Publications

ACS Publications · 2 months ago

Novo Nordisk's Ozempic® pill, the only FDA-approved oral peptide GLP-1 medication for adults with type 2 diabetes, soon to be available in the US - PR Newswire

PR Newswire · 1 month ago

News aggregated via Google News. Inclusion does not imply endorsement.

Medical Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. Peptide therapies have not been evaluated by the FDA for most listed indications.All prices shown are estimates based on publicly available data and may not reflect current pricing — providers and brands set their own prices and can change them at any time. Always verify pricing directly with the provider before purchasing. Consult a licensed healthcare provider before starting any peptide protocol.

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