Weight Loss & MetabolicStrong Evidence

Mazdutide Peptide Therapy

Benefits, Side Effects, Cost & Protocols

Mazdutide peptide molecular structure diagram from PubChem

Mazdutide is a dual GLP-1/glucagon receptor agonist developed by Innovent Biologics for the treatment of obesity and type 2 diabetes. It combines GLP-1-mediated appetite suppression with glucagon-mediated energy expenditure increases.

ByChris Riley(CFA)&Alex Evans, PharmD, MBA(PharmD, MBA)|Updated May 19, 2026

Clinically Reviewed

Reviewed by Alex Evans, PharmD, MBA · Updated May 2026

Evidence-Based

Sourced from FDA, PubMed & ClinicalTrials.gov · View sources

FDA Status

Research Only Not currently approved for human use in the US. Available as a research compound. Not eligible for compounding.

Evidence

Strong Evidence

Who Is Mazdutide Best For?

Weight management researchDual mechanismMetabolic enhancement

How Mazdutide Works

Dual GLP-1 and glucagon receptor agonist that may enhance metabolic effects through complementary pathways.

Mazdutide FAQ

What is MAZDUTIDE?

Mazdutide is an emerging dual agonist peptide targeting both GLP-1 and glucagon receptors, representing the next generation of weight management research compounds.

How does MAZDUTIDE work?

Dual GLP-1 and glucagon receptor agonist that may enhance metabolic effects through complementary pathways.

Is MAZDUTIDE legal to buy?

MAZDUTIDE is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.

Where can I buy MAZDUTIDE?

MAZDUTIDE is available as a research compound from verified online vendors. Always verify third-party testing before purchasing.

What category does MAZDUTIDE belong to?

MAZDUTIDE is primarily classified as a weight loss & metabolic peptide. Peptides researched for their effects on weight management, fat metabolism, appetite regulation, and metabolic enhancement. This category includes GLP-1 agonists, dual/triple agonists, and other metabolic peptides.

What are the research benefits of MAZDUTIDE?

MAZDUTIDE has been studied for: Weight management research, Dual mechanism, Metabolic enhancement. New dual agonist; emerging weight loss research peptide.

Key Studies

39 total on PubMed29 human trials

Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes

Guo L, Zhang B, Xue X et al

NaturePhase 3

Mazdutide superior to dulaglutide for HbA1c reduction and weight loss in Chinese adults with type 2 diabetes.

Mazdutide superior to dulaglutide for HbA1c reduction and weight loss in Chinese adults with type 2 diabetes

Once-Weekly Mazdutide in Chinese Adults with Obesity or Overweight

Ji L, Jiang H, Bi Y et al

N Engl J MedPhase 3

Mazdutide 4-6 mg reduced body weight by 11-14% at 48 weeks vs 0.3% with placebo.

Mazdutide 4-6 mg reduced body weight by 11-14% at 48 weeks vs 0.3% with placebo

Mazdutide versus Semaglutide for the treatment of type 2 diabetes and obesity: Rationale, design and baseline data of DREAMS-3 phase 3 trial

Luo Y, Jiang H, Shi B et al

Contemp Clin Trials · Contemp Clin TrialsPhase 3

Mazdutide vs semaglutide efficacy and safety in Chinese adults with type 2 diabetes and obesity.

Mazdutide vs semaglutide efficacy and safety in Chinese adults with type 2 diabetes and obesity

Mazdutide versus placebo in Chinese adults with type 2 diabetes

Mazdutide Compound Data

Molecular Formula

C207H317N45O65

Molecular Weight

4476 g/mol

IUPAC Name

20-[[(1S)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-2-methyl-propanoyl]amino]-5-oxo-pentanoyl]amino]acetyl]amino]-3-hydroxy-butanoyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]amino]-3-carboxy-propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxy-propanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methyl-pentanoyl]amino]-3-carboxy-propanoyl]amino]-4-carboxy-butanoyl]amino]hexanoyl]amino]hexanoyl]amino]propanoyl]amino]-6-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[2-[[2-[(2S)-2-[[(1S)-2-[(2-amino-2-oxo-ethyl)amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]pyrrolidin-1-yl]-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-3-carboxy-propyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-3-carboxy-propyl]carbamoyl]-2-methyl-propyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-3-carboxy-propyl]amino]-6-oxo-hexyl]amino]-2-oxo-ethoxy]ethoxy]ethylamino]-2-oxo-ethoxy]ethoxy]ethylamino]-1-carboxy-4-oxo-butyl]amino]-20-oxo-icosanoic acid

View full compound on PubChem

Mazdutide News

Mazdutide vs. Tirzepatide: Which Is Better for Weight Control? - Ro

Ro · 18 days ago

Once-Weekly Mazdutide in Chinese Adults with Obesity or Overweight - The New England Journal of Medicine

The New England Journal of Medicine · 10 months ago

Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes - Nature

Nature · 5 months ago

Mazdutide Outperforms Dulaglutide in Type 2 Diabetes Trial - EMJ

EMJ · 4 months ago

Innovent Announces Mazdutide, First Dual GCG/GLP-1 Receptor Agonist, Received Approval from China's NMPA for Chronic Weight Management - PR Newswire

PR Newswire · 10 months ago

News aggregated via Google News. Inclusion does not imply endorsement.

Medical Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. Peptide therapies have not been evaluated by the FDA for most listed indications.All prices shown are estimates based on publicly available data and may not reflect current pricing — providers and brands set their own prices and can change them at any time. Always verify pricing directly with the provider before purchasing. Consult a licensed healthcare provider before starting any peptide protocol.

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