Skin, Hair & CosmeticModerate Evidence

Matrixyl Peptide Therapy

Benefits, Side Effects, Cost & Protocols

Matrixyl peptide molecular structure diagram from PubChem

Matrixyl (palmitoyl pentapeptide-4) is a cosmetic peptide that stimulates collagen synthesis and skin repair. It signals the skin to produce more collagen and fibronectin, reducing the appearance of fine lines and wrinkles. It is one of the most clinically studied anti-aging cosmetic peptides.

ByChris Riley(CFA)&Alex Evans, PharmD, MBA(PharmD, MBA)|Updated June 8, 2026

Clinically Reviewed

Reviewed by Alex Evans, PharmD, MBA · Updated June 2026

Evidence-Based

Sourced from FDA, PubMed & ClinicalTrials.gov · View sources

FDA Status

Research Only Not currently approved for human use in the US. Available as a research compound. Not eligible for compounding.

Evidence

Moderate Evidence

How Matrixyl Works

Matrikine peptide that mimics collagen breakdown fragments, signaling fibroblasts to increase synthesis of collagen I, III, IV, fibronectin, and hyaluronic acid.

Matrixyl FAQ

What is MATRIXYL?

Matrixyl (Palmitoyl Pentapeptide-4) is a lipopeptide signal peptide that stimulates collagen and extracellular matrix production, widely used in anti-aging skincare formulations.

How does MATRIXYL work?

Matrikine peptide that mimics collagen breakdown fragments, signaling fibroblasts to increase synthesis of collagen I, III, IV, fibronectin, and hyaluronic acid.

Is MATRIXYL legal to buy?

MATRIXYL is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.

Where can I buy MATRIXYL?

MATRIXYL has mixed availability - it can be found through both compounding pharmacies (with prescription) and research suppliers.

What category does MATRIXYL belong to?

MATRIXYL is primarily classified as a skin, hair & cosmetic peptide. Peptides studied for cosmetic applications including skin rejuvenation, collagen production, tanning, hair growth, and anti-wrinkle effects.

What are the research benefits of MATRIXYL?

MATRIXYL has been studied for: Collagen synthesis, ECM production, Wrinkle reduction, Skin firmness. One of the most well-studied cosmetic peptides. Multiple variants (Matrixyl 3000, Matrixyl Synthe'6).

Key Studies

11 total on PubMed7 human trials

Röper B, Kaisig D, Auer F et al

Strahlenther Onkol · Strahlenther OnkolPhase 2

50 Gy radiotherapy course

Theta-Cream showed no advantage over Bepanthol lotion for preventing acute radiation skin toxicity

Self-Assembly and Wound Healing Activity of Biomimetic Cycloalkane-Based Lipopeptides

Adak A, Castelletto V, Hamley IW et al

ACS Appl Mater InterfacesAnimal

DDKT lipopeptide enhanced wound healing in diabetic rats with increased collagen and neovascularization

N-Terminal Acetylation and C-Terminal Amidation of Spirulina platensis-Derived Hexapeptide: Anti-Photoaging Activity and Proteomic Analysis

Zeng Q, Jiang J, Wang J et al

Mar Drugs · Mar DrugsAnimal

Acetylated hexapeptide reduced UVB-induced skin damage and oxidative stress markers in vitro and in vivo

Synergistic Effects of Injectable Platelet-Rich Fibrin and Bioactive Peptides on Dermal Fibroblast Viability and Extracellular Matrix Gene Expression: An In Vitro Study

Paccola AGL, Santos TMCD, Minelo MC et al

In Vitro · Molecules

Matrixyl Compound Data

Molecular Formula

C39H75N7O10

Molecular Weight

802.1 g/mol

IUPAC Name

(2S)-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-butanoyl]amino]hexanoyl]amino]-3-hydroxy-propanoic acid

View full compound on PubChem

Matrixyl News

Argireline Serums Are Growing in Popularity for Their "Botox-Like" Effects — These Are Our 10 Favorites - People.com

People.com · 3 days ago

Your Anti-Aging Routine May Not Yet Include Matrixyl, but Maybe It Should, Say Fans of This $11 ‘Holy Grail’ Serum - Real Simple

Real Simple · 21 days ago

Croda creates evolution to Matrixyl peptide technology for anti-aging - Personal Care Insights

Personal Care Insights · 1 month ago

Undereye Puffiness? Fine Lines? There’s a Peptide Eye Cream For That - Allure

Allure · 22 days ago

Matrixyl® Neolide™ Croda Beauty Actives unveils the next chapter of an iconic peptide - Global Cosmetics News

Global Cosmetics News · 1 month ago

This peptide serum is my best gate-kept secret for smooth skin - Glamour UK

Glamour UK · 23 days ago

What Peptides Can Tell Us About the Future of Beauty - Vogue

Vogue · 1 month ago

Peptide serums that actually make skin look firm, plump and glowy — 14 tried and tested - Cosmopolitan

Cosmopolitan · 1 month ago

News aggregated via Google News. Inclusion does not imply endorsement.

Medical Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. Peptide therapies have not been evaluated by the FDA for most listed indications.All prices shown are estimates based on publicly available data and may not reflect current pricing — providers and brands set their own prices and can change them at any time. Always verify pricing directly with the provider before purchasing. Consult a licensed healthcare provider before starting any peptide protocol.

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