Sexual Function & LibidoModerate Evidence

Kisspeptin-10 Peptide Therapy

Benefits, Side Effects, Cost & Protocols

Kisspeptin-10 peptide molecular structure diagram from PubChem

Kisspeptin is a protein encoded by the KISS1 gene that plays a critical role in initiating GnRH secretion at puberty. Kisspeptin-GPR54 signaling triggers the release of gonadotropin-releasing hormone from the hypothalamus, stimulating LH and FSH release for reproductive hormone regulation.

ByChris Riley(CFA)&Alex Evans, PharmD, MBA(PharmD, MBA)|Updated May 19, 2026

Clinically Reviewed

Reviewed by Alex Evans, PharmD, MBA · Updated May 2026

Evidence-Based

Sourced from FDA, PubMed & ClinicalTrials.gov · View sources

FDA Status

Research Only Not currently approved for human use in the US. Available as a research compound. Not eligible for compounding.

Evidence

Moderate Evidence

Who Is Kisspeptin-10 Best For?

Libido research1 preclinical studyHormone axis stimulationReproductive functionLimited human trials or strong preclinical

How Kisspeptin-10 Works

Stimulates GnRH release, which triggers the hypothalamic-pituitary-gonadal axis, influencing testosterone, LH, and FSH levels.

Kisspeptin-10 FAQ

What is KISSPEPTIN-10?

Kisspeptin-10 is a neuropeptide researched for its central role in regulating the reproductive hormone axis and its potential effects on libido and sexual function.

How does KISSPEPTIN-10 work?

Stimulates GnRH release, which triggers the hypothalamic-pituitary-gonadal axis, influencing testosterone, LH, and FSH levels.

Is KISSPEPTIN-10 legal to buy?

KISSPEPTIN-10 is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.

Where can I buy KISSPEPTIN-10?

KISSPEPTIN-10 has mixed availability - it can be found through both compounding pharmacies (with prescription) and research suppliers.

What category does KISSPEPTIN-10 belong to?

KISSPEPTIN-10 is primarily classified as a sexual function & libido peptide. Peptides researched for their effects on sexual function, libido, and reproductive health.

What are the research benefits of KISSPEPTIN-10?

KISSPEPTIN-10 has been studied for: Libido research, Hormone axis stimulation, Reproductive function. Libido/hormone stimulation; reproductive research peptide.

Key Studies

937 total on PubMed0

Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men

Jayasena CN, Abbara A, Narayanaswamy S et al

Hum Reprod · Hum ReprodPhase 1

3 hours per session

GnRH was 2-3 fold more potent than kisspeptin isoforms in stimulating gonadotrophin secretion

Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men

George JT, Veldhuis JD, Roseweir AK et al

J Clin Endocrinol MetabPhase 1

Kisspeptin-10 dose-dependently increases LH pulse frequency and testosterone secretion in healthy men

Correlation of Kisspeptin-10 level and fetal well-being in preeclamptic patients

Taiwan J Obstet Gynecol

Kisspeptin-10 level inversely correlates with preeclampsia severity and fetal growth parameters

The roles of kisspeptin and neurokinin B in GnRH pulse generation in humans, and their potential clinical application

J Neuroendocrinol

Continuous kisspeptin-10 infusion increases LH pulse frequency in humans without desensitization

Kisspeptin-10 Compound Data

Molecular Formula

C63H83N17O14

Molecular Weight

1302.4 g/mol

IUPAC Name

(2S)-N-[(1S)-2-[[(1S)-3-amino-1-[[(1S)-2-[[(1S)-2-[[2-[[(1S)-1-[[(1S)-1-[[(1S)-2-amino-1-benzyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]amino]-1-benzyl-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-3-oxo-propyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]butanediamide

View full compound on PubChem

Kisspeptin-10 News

Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer - Nature

Nature · 7 months ago

Kisspeptin and Erectile Dysfunction: What the Emerging Research Actually Shows - Portal CNJ

Portal CNJ · 9 days ago

Wait, So Are Peptides Legal Now? - Yahoo

Yahoo · 25 days ago

Miracle Molecules or Medical Mirage? The Peptide Debate - American Council on Science and Health

American Council on Science and Health · 1 month ago

Kisspeptin Erectile Dysfunction: What the Current Evidence Actually Shows - City University of Hong Kong

City University of Hong Kong · 9 days ago

News aggregated via Google News. Inclusion does not imply endorsement.

Medical Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. Peptide therapies have not been evaluated by the FDA for most listed indications.All prices shown are estimates based on publicly available data and may not reflect current pricing — providers and brands set their own prices and can change them at any time. Always verify pricing directly with the provider before purchasing. Consult a licensed healthcare provider before starting any peptide protocol.

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