Growth Hormone SecretionModerate Evidence

Ipamorelin Peptide Therapy

Benefits, Side Effects, Cost & Protocols

Ipamorelin peptide molecular structure diagram from PubChem

Ipamorelin is a selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS) and a growth hormone secretagogue. It is a pentapeptide derived from GHRP-1 that selectively stimulates growth hormone release without significantly affecting cortisol, prolactin, or ACTH levels.

ByChris Riley(CFA)&Alex Evans, PharmD, MBA(PharmD, MBA)|Updated May 19, 2026

Clinically Reviewed

Reviewed by Alex Evans, PharmD, MBA · Updated May 2026

Evidence-Based

Sourced from FDA, PubMed & ClinicalTrials.gov · View sources

FDA Status

Compounding Allowed Currently on FDA bulk drug substance nomination list for compounding. Growth hormone secretagogue.

Evidence

Moderate Evidence

Compare Ipamorelin Prices

1 provider offering Ipamorelin — sorted lowest price first

Defy Medical

Ipamorelin/CJC-1295 Blend· 300mcg nightly

ClinicalRx

$199

/month

Get Started

Prices shown are estimates based on publicly available data and may not reflect current pricing. Actual costs may vary by location, insurance, dosage, and formulation. Always verify directly with the provider.

Who Is Ipamorelin Best For?

Clean GH release2 preclinical studiesMinimal side effectsAnti-aging researchSleep qualityRecoveryLimited human trials or strong preclinical

How Ipamorelin Works

Selective ghrelin receptor agonist that stimulates clean GH release with minimal side effects and no impact on other hormones.

Ipamorelin FAQ

What is IPAMORELIN?

Ipamorelin is one of the most selective and cleanest growth hormone-releasing peptides, producing GH release without significant effects on cortisol or prolactin. It's widely available through compounding pharmacies.

How does IPAMORELIN work?

Selective ghrelin receptor agonist that stimulates clean GH release with minimal side effects and no impact on other hormones.

Is IPAMORELIN legal to buy?

IPAMORELIN requires a prescription from a licensed healthcare provider. It is legal to purchase with a valid prescription from authorized pharmacies.

Where can I buy IPAMORELIN?

IPAMORELIN is available through compounding pharmacies with a valid prescription. Our directory lists verified pharmacies that compound this peptide.

What category does IPAMORELIN belong to?

IPAMORELIN is primarily classified as a growth hormone secretion peptide. Peptides that stimulate or support growth hormone release, including GHRH analogs, GHRPs, and direct GH compounds for muscle, recovery, and anti-aging research.

What are the research benefits of IPAMORELIN?

IPAMORELIN has been studied for: Clean GH release, Minimal side effects, Anti-aging research, Sleep quality, Recovery. Selective, clean GH release; available via compounding pharmacies.

Key Studies

51 total on PubMed0

Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients

Beck DE, Sweeney WB, McCarter MD et al

Int J Colorectal DisPhase 2

Ipamorelin was well-tolerated but showed no significant difference vs placebo for postoperative ileus.

Ipamorelin was well-tolerated but showed no significant difference vs placebo for postoperative ileus

Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers

Gobburu JV, Agersø H, Jusko WJ et al

Pharm Res · Pharm ResPhase 1

Single dose escalation study

Ipamorelin shows dose-proportional pharmacokinetics with 2-hour half-life and potent GH stimulation

Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin

Semenistaya E, Zvereva I, Thomas A et al

Case Series · Drug Test Anal

2 days post-administration

GHRPs and metabolites detected in urine with varying detection windows after nasal administration

A high-throughput LC-MS/MS screen for GHRP in equine and human urine, featuring peptide derivatization for improved chromatography

Ipamorelin Compound Data

Molecular Formula

C38H49N9O5

Molecular Weight

711.9 g/mol

IUPAC Name

(2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[(2-amino-2-methyl-propanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(2-naphthyl)propanoyl]amino]-3-phenyl-propanoyl]amino]hexanamide

View full compound on PubChem

Ipamorelin News

The peptide problem: Hype is outrunning the evidence - The Conversation

The Conversation · 12 days ago

Umbrella Lab Announces Documentation And Traceability Update For Ipamorelin Peptide - mydailyrecord.com

mydailyrecord.com · 3 days ago

RFK Jr. May Reverse a Peptide Ban He Calls “Illegal.” Former FDA Officials Say He Mischaracterized Their Work. - ProPublica

ProPublica · 1 month ago

Peptide Stacking Is Everywhere—But Should You Be Doing It? - Goop

Goop · 1 month ago

The Peptide Craze - Ground Truths | Eric Topol

Ground Truths | Eric Topol · 10 months ago

News aggregated via Google News. Inclusion does not imply endorsement.

Medical Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. Peptide therapies have not been evaluated by the FDA for most listed indications.All prices shown are estimates based on publicly available data and may not reflect current pricing — providers and brands set their own prices and can change them at any time. Always verify pricing directly with the provider before purchasing. Consult a licensed healthcare provider before starting any peptide protocol.

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