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Hexarelin peptide therapy
Growth Hormone SecretionModerate Evidence

Hexarelin Peptide Therapy

Benefits, Side Effects, Cost & Protocols

Hexarelin peptide molecular structure diagram from PubChem

Hexarelin (Examorelin) is a potent, synthetic, peptidic, orally-active, centrally-penetrant, and highly selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR). It is a hexapeptide derived from GHRP-6 developed by Mediolanum Farmaceutici.

ByChris Riley(CFA)&Alex Evans, PharmD, MBA(PharmD, MBA)|Updated

Clinically Reviewed

Reviewed by Alex Evans, PharmD, MBA · Updated May 2026

Evidence-Based

Sourced from FDA, PubMed & ClinicalTrials.gov · View sources

FDA Status
Research Only Not currently approved for human use in the US. Available as a research compound. Not eligible for compounding.
Evidence
Moderate Evidence
Category
Growth Hormone Secretion

How Hexarelin Works

Synthetic hexapeptide that strongly activates ghrelin receptors, producing robust and sustained GH release.

Hexarelin FAQ

What is HEXARELIN?

Hexarelin is considered one of the most potent growth hormone-releasing peptides available, producing significant GH secretion even after repeated administration.

How does HEXARELIN work?

Synthetic hexapeptide that strongly activates ghrelin receptors, producing robust and sustained GH release.

Is HEXARELIN legal to buy?

HEXARELIN is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.

Where can I buy HEXARELIN?

HEXARELIN is available as a research compound from verified online vendors. Always verify third-party testing before purchasing.

What category does HEXARELIN belong to?

HEXARELIN is primarily classified as a growth hormone secretion peptide. Peptides that stimulate or support growth hormone release, including GHRH analogs, GHRPs, and direct GH compounds for muscle, recovery, and anti-aging research.

What are the research benefits of HEXARELIN?

HEXARELIN has been studied for: Potent GH release, Muscle research, Performance studies. Potent GHRP; strongest in class.

Key Studies

311 total on PubMed191 human trials

Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects

Arvat E, Gianotti L, Grottoli S et al

J Clin Endocrinol MetabRCT

Hexarelin combined with GHRH or arginine restores blunted growth hormone response in elderly subjects

Desmopressin and hexarelin tests in alcohol-induced pseudo-Cushing's syndrome

Coiro V, Volpi R, Capretti L et al

J Intern MedRCT

Hexarelin test effectively differentiates Cushing's disease from alcohol-induced pseudo-Cushing's syndrome

The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity

Massoud AF, Hindmarsh PC, Matthews DR et al

Clin Endocrinol (Oxf) · Clin Endocrinol (Oxf)RCT

Hexarelin and GHRH show synergistic GH secretion on first administration; synergism is lost on repeated dosing

The effect of body composition on hexarelin-induced growth hormone release in normal elderly subjects

Clin Endocrinol (Oxf) · Clin Endocrinol (Oxf)

Hexarelin Compound Data

Hexarelin peptide chemical structure and molecular formula from PubChem
Molecular Formula
C47H58N12O6
Molecular Weight
887.0 g/mol
IUPAC Name
(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenyl-propanoyl]amino]hexanamide
View full compound on PubChem
Medical Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. Peptide therapies have not been evaluated by the FDA for most listed indications.All prices shown are estimates based on publicly available data and may not reflect current pricing — providers and brands set their own prices and can change them at any time. Always verify pricing directly with the provider before purchasing. Consult a licensed healthcare provider before starting any peptide protocol.

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