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Growth Hormone SecretionModerate evidence

Follistatin

Peptide therapy: benefits, side effects, cost and protocols

Follistatin is an autocrine glycoprotein encoded by the FST gene and expressed in nearly all tissues of higher animals. It functions as an activin-binding protein that inhibits FSH biosynthesis and secretion, and has been studied for its role in muscle growth and myostatin inhibition.

ByChris Riley(CFA)|Updated

Sources: FDA / PubMed / ClinicalTrials.gov View

Spec sheet

FDA status
Research Only Not currently approved for human use in the US. Available as a research compound. Not eligible for compounding.
Evidence
Moderate Evidence
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Who it's for

Who Follistatin is usually considered for

  • Muscle growth promotion
  • Myostatin inhibition
  • Strength enhancement
  • Body composition improvement
  • Limited human trials or strong preclinical

Mechanism

How Follistatin works

Binds to and neutralizes myostatin (a muscle growth inhibitor) and activin. By blocking these proteins, it may remove natural limits on muscle growth and development.

Evidence

Key studies

3,241 papers on PubMed

  1. 01

    Effects of Resistance Training on Muscular Adaptations and Inflammatory Markers in Overweight and Obese Men

  2. 02

    Bagheri N, Bagheri R, Mesinovic J et al

    Med Sci Sports Exerc / Med Sci Sports Exerc / RCT

    Combined resistance training increased muscle mass and reduced inflammation more than upper or lower body training alone.

  3. 03

    Combined resistance training increased muscle mass and reduced inflammation more than upper or lower body training alone

    Physiol Res / Physiol Res / RCT

    Creatine supplementation with resistance training increased strength and muscle mass while improving anabolic hormone ratios.

  4. 04

    Creatine supplementation with resistance training increased strength and muscle mass while improving anabolic hormone ratios

  5. 05

    Effects of 12-week whole-body vibration training versus resistance training in older people with sarcopenia

  6. 06

    Zhuang M, Gu Y, Wang Z et al

    Sci Rep / Sci Rep / RCT

    Both whole-body vibration and resistance training improved muscle strength and physical performance; resistance training superior for knee extension strength.

  7. 07

    Both whole-body vibration and resistance training improved muscle strength and physical performance; resistance training superior for knee extension strength

  8. 08

    Effects of 16 Weeks of Resistance Training on Muscle Quality and Muscle Growth Factors in Older Adult Women with Sarcopenia: A Randomized Controlled Trial

  9. 09

    Seo MW, Jung SW, Kim SW et al

    Int J Environ Res Public Health / RCT

    Resistance training improved functional fitness and grip strength while preventing age-related intramuscular fat increases.

  10. 10

    Resistance training improved functional fitness and grip strength while preventing age-related intramuscular fat increases

FAQ

Follistatin questions

What is FOLLISTATIN?

Follistatin is a naturally occurring glycoprotein researched for its ability to inhibit myostatin and activin, potentially promoting significant muscle growth. It is one of the most studied compounds for muscle development.

How does FOLLISTATIN work?

Binds to and neutralizes myostatin (a muscle growth inhibitor) and activin. By blocking these proteins, it may remove natural limits on muscle growth and development.

Is FOLLISTATIN legal to buy?

FOLLISTATIN is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.

Where can I buy FOLLISTATIN?

FOLLISTATIN is available as a research compound from verified online vendors. Always verify third-party testing before purchasing.

What category does FOLLISTATIN belong to?

FOLLISTATIN is primarily classified as a growth hormone secretion peptide. Peptides that stimulate or support growth hormone release, including GHRH analogs, GHRPs, and direct GH compounds for muscle, recovery, and anti-aging research.

What are the research benefits of FOLLISTATIN?

FOLLISTATIN has been studied for: Muscle growth promotion, Myostatin inhibition, Strength enhancement, Body composition improvement. Powerful myostatin inhibitor; significant research interest for muscle wasting conditions.

News

Follistatin in the news

News aggregated via Google News. Inclusion does not imply endorsement.

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