Growth Hormone SecretionModerate Evidence

Follistatin Peptide Therapy

Benefits, Side Effects, Cost & Protocols

Follistatin is an autocrine glycoprotein encoded by the FST gene and expressed in nearly all tissues of higher animals. It functions as an activin-binding protein that inhibits FSH biosynthesis and secretion, and has been studied for its role in muscle growth and myostatin inhibition.

ByChris Riley(CFA)&Alex Evans, PharmD, MBA(PharmD, MBA)|Updated May 19, 2026

Clinically Reviewed

Reviewed by Alex Evans, PharmD, MBA · Updated May 2026

Evidence-Based

Sourced from FDA, PubMed & ClinicalTrials.gov · View sources

FDA Status

Research Only Not currently approved for human use in the US. Available as a research compound. Not eligible for compounding.

Evidence

Moderate Evidence

Who Is Follistatin Best For?

Muscle growth promotionMyostatin inhibitionStrength enhancementBody composition improvementLimited human trials or strong preclinical

How Follistatin Works

Binds to and neutralizes myostatin (a muscle growth inhibitor) and activin. By blocking these proteins, it may remove natural limits on muscle growth and development.

Follistatin FAQ

What is FOLLISTATIN?

Follistatin is a naturally occurring glycoprotein researched for its ability to inhibit myostatin and activin, potentially promoting significant muscle growth. It is one of the most studied compounds for muscle development.

How does FOLLISTATIN work?

Binds to and neutralizes myostatin (a muscle growth inhibitor) and activin. By blocking these proteins, it may remove natural limits on muscle growth and development.

Is FOLLISTATIN legal to buy?

FOLLISTATIN is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.

Where can I buy FOLLISTATIN?

FOLLISTATIN is available as a research compound from verified online vendors. Always verify third-party testing before purchasing.

What category does FOLLISTATIN belong to?

FOLLISTATIN is primarily classified as a growth hormone secretion peptide. Peptides that stimulate or support growth hormone release, including GHRH analogs, GHRPs, and direct GH compounds for muscle, recovery, and anti-aging research.

What are the research benefits of FOLLISTATIN?

FOLLISTATIN has been studied for: Muscle growth promotion, Myostatin inhibition, Strength enhancement, Body composition improvement. Powerful myostatin inhibitor; significant research interest for muscle wasting conditions.

Key Studies

3,192 total on PubMed0

Effects of Resistance Training on Muscular Adaptations and Inflammatory Markers in Overweight and Obese Men

Bagheri N, Bagheri R, Mesinovic J et al

Med Sci Sports Exerc · Med Sci Sports ExercRCT

Combined resistance training increased muscle mass and reduced inflammation more than upper or lower body training alone.

Combined resistance training increased muscle mass and reduced inflammation more than upper or lower body training alone

Physiol Res · Physiol ResRCT

Creatine supplementation with resistance training increased strength and muscle mass while improving anabolic hormone ratios.

Creatine supplementation with resistance training increased strength and muscle mass while improving anabolic hormone ratios

Effects of 12-week whole-body vibration training versus resistance training in older people with sarcopenia

Zhuang M, Gu Y, Wang Z et al

Sci Rep · Sci RepRCT

Both whole-body vibration and resistance training improved muscle strength and physical performance; resistance training superior for knee extension strength.

Both whole-body vibration and resistance training improved muscle strength and physical performance; resistance training superior for knee extension strength

Effects of 16 Weeks of Resistance Training on Muscle Quality and Muscle Growth Factors in Older Adult Women with Sarcopenia: A Randomized Controlled Trial

Seo MW, Jung SW, Kim SW et al

Int J Environ Res Public HealthRCT

Resistance training improved functional fitness and grip strength while preventing age-related intramuscular fat increases.

Resistance training improved functional fitness and grip strength while preventing age-related intramuscular fat increases

Follistatin News

Follistatin-344: Myostatin Signaling, Tissue Plasticity, and Molecular Modulation Research - HIT Consultant

HIT Consultant · 10 days ago

New Research Highlights 10 Peptides You Shouldn’t Be Using - Outside Magazine

Outside Magazine · 20 days ago

Myostatin Inhibitor Penis Enlargement: What the Science Actually Shows - Portal CNJ

Portal CNJ · 9 days ago

Follistatin-344: A Regulatory Peptide at the Crossroads of Growth Signaling, Tissue Plasticity, and Molecular Homeostasis - BOXROX

BOXROX · 2 months ago

Follistatin-344: A Versatile Peptide Under Investigation - 3-mob.com

3-mob.com · 4 months ago

Peptides 101: What You Need to Know Before Stacking for Strength - Men's Journal

Men's Journal · 7 months ago

Follistatin-344 Peptide: A Versatile Molecule in Scientific Exploration - Nation Thailand

Nation Thailand · 11 months ago

Follistatin secretion is enhanced by protein, but not glucose or fat ingestion, in obese persons independently of previous gastric bypass surgery - American Physiological Society Journal

American Physiological Society Journal · 63 months ago

News aggregated via Google News. Inclusion does not imply endorsement.

Medical Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. Peptide therapies have not been evaluated by the FDA for most listed indications.All prices shown are estimates based on publicly available data and may not reflect current pricing — providers and brands set their own prices and can change them at any time. Always verify pricing directly with the provider before purchasing. Consult a licensed healthcare provider before starting any peptide protocol.

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