Dihexa Peptide Therapy
Benefits, Side Effects, Cost & Protocols
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is an oligopeptide drug derived from angiotensin IV that has been found to be a potent cognitive enhancer in animal models. It acts as a hepatocyte growth factor (HGF) receptor agonist and has shown the ability to cross the blood-brain barrier.
Clinically Reviewed
Reviewed by Alex Evans, PharmD, MBA · Updated May 2026
Evidence-Based
Sourced from FDA, PubMed & ClinicalTrials.gov · View sources
Who Is Dihexa Best For?
How Dihexa Works
Binds to hepatocyte growth factor (HGF) receptor, dramatically increasing its activity. This promotes synaptogenesis, neuronal survival, and neuroplasticity through the HGF/c-Met pathway.
Dihexa FAQ
What is DIHEXA?
Dihexa is a potent nootropic peptide derived from angiotensin IV, researched for its remarkable ability to enhance cognitive function and promote neuroplasticity. It is considered one of the most powerful cognitive-enhancing peptides studied.
How does DIHEXA work?
Binds to hepatocyte growth factor (HGF) receptor, dramatically increasing its activity. This promotes synaptogenesis, neuronal survival, and neuroplasticity through the HGF/c-Met pathway.
Is DIHEXA legal to buy?
DIHEXA is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.
Where can I buy DIHEXA?
DIHEXA is available as a research compound from verified online vendors. Always verify third-party testing before purchasing.
What category does DIHEXA belong to?
DIHEXA is primarily classified as a cognitive enhancement peptide. Nootropic peptides researched for cognitive function, memory, focus, neuroprotection, and neurogenesis.
What are the research benefits of DIHEXA?
DIHEXA has been studied for: Cognitive enhancement, Memory improvement, Neuroplasticity support, Neuroprotection, Learning enhancement. Extremely potent nootropic; 10 million times more potent than BDNF in some assays.
Key Studies
18 total on PubMed9 human trialsCognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies
Neurosci Biobehav Rev · Neurosci Biobehav Rev
Angiotensin IV and analogs improved cognitive performance in normal and impaired animal models
Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats
Wells RG, Azzam AF, Hiller AL et al
J Huntingtons DisAnimal
PNB-0408 did not protect rats from 3-NP-induced Huntington's disease-like symptoms.
PNB-0408 did not protect rats from 3-NP-induced Huntington's disease-like symptoms
The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system
Benoist CC, Kawas LH, Zhu M et al
J Pharmacol Exp TherAnimal
Dihexa's procognitive activity depends on HGF/c-Met system activation
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
J Am Acad Orthop Surg Glob Res Rev
Therapeutic peptides modulate tissue regeneration and neuroplasticity pathways in orthopaedic applications
Dihexa Compound Data
Dihexa News
Drug that shifts brain’s signaling balance could treat autism - The Transmitter
The Transmitter · 24 months ago
Everything You Need to Know About the FDA Peptide Ban - Hone Health
Hone Health · 26 months ago
RFK Jr. forces FDA to reconsider 12 unproven peptides after 2023 ban - Ars Technica
Ars Technica · 1 month ago
Peptide Drug Rebuilds Brain Connections in Alzheimer’s Disease - Genetic Engineering and Biotechnology News
Genetic Engineering and Biotechnology News · 165 months ago
FDA considers adding a dozen peptides to its bulk drug compounding list - RAPS.org
RAPS.org · 1 month ago
News aggregated via Google News. Inclusion does not imply endorsement.
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