Cognitive EnhancementEmerging evidence

Dihexa

Peptide therapy: benefits, side effects, cost and protocols

C₂₇H₄₄N₄O₅

504.7 g/mol / CID 129010512

Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is an oligopeptide drug derived from angiotensin IV that has been found to be a potent cognitive enhancer in animal models. It acts as a hepatocyte growth factor (HGF) receptor agonist and has shown the ability to cross the blood-brain barrier.

ByChris Riley(CFA)|Updated October 10, 2026

Sources: FDA / PubMed / ClinicalTrials.gov View

Spec sheet

FDA status: Banned from Compounding March 2024 Not eligible for compounding. Removed from bulk drug substance nomination list.
Evidence: Emerging Evidence

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Who it's for

Who Dihexa is usually considered for

Cognitive enhancement
Memory improvement
Neuroplasticity support
Neuroprotection
1 preclinical study
Learning enhancement
Primarily animal or early-phase data

Mechanism

How Dihexa works

Binds to hepatocyte growth factor (HGF) receptor, dramatically increasing its activity. This promotes synaptogenesis, neuronal survival, and neuroplasticity through the HGF/c-Met pathway.

Evidence

Key studies

19 papers on PubMed

01
Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies
Neurosci Biobehav Rev / Neurosci Biobehav Rev
02
Angiotensin IV and analogs improved cognitive performance in normal and impaired animal models
03
Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats
04
Wells RG, Azzam AF, Hiller AL et al
J Huntingtons Dis / Animal
PNB-0408 did not protect rats from 3-NP-induced Huntington's disease-like symptoms.
05
PNB-0408 did not protect rats from 3-NP-induced Huntington's disease-like symptoms
06
The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system
07
Benoist CC, Kawas LH, Zhu M et al
J Pharmacol Exp Ther / Animal
08
Dihexa's procognitive activity depends on HGF/c-Met system activation
09
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
J Am Acad Orthop Surg Glob Res Rev
10
Therapeutic peptides modulate tissue regeneration and neuroplasticity pathways in orthopaedic applications

Compound

Dihexa compound data

Formula: C27H44N4O5
Mol. weight: 504.7 g/mol
PubChem CID: 129010512 ↗
IUPAC: (2S,3S)-N-(6-amino-6-oxo-hexyl)-2-[[(2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-pentanamide

FAQ

Dihexa questions

What is DIHEXA?

Dihexa is a potent nootropic peptide derived from angiotensin IV, researched for its remarkable ability to enhance cognitive function and promote neuroplasticity. It is considered one of the most powerful cognitive-enhancing peptides studied.

How does DIHEXA work?

Binds to hepatocyte growth factor (HGF) receptor, dramatically increasing its activity. This promotes synaptogenesis, neuronal survival, and neuroplasticity through the HGF/c-Met pathway.

Is DIHEXA legal to buy?

DIHEXA is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.

Where can I buy DIHEXA?

DIHEXA is available as a research compound from verified online vendors. Always verify third-party testing before purchasing.

What category does DIHEXA belong to?

DIHEXA is primarily classified as a cognitive enhancement peptide. Nootropic peptides researched for cognitive function, memory, focus, neuroprotection, and neurogenesis.

What are the research benefits of DIHEXA?

DIHEXA has been studied for: Cognitive enhancement, Memory improvement, Neuroplasticity support, Neuroprotection, Learning enhancement. Extremely potent nootropic; 10 million times more potent than BDNF in some assays.

News

Dihexa in the news

News aggregated via Google News. Inclusion does not imply endorsement.

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