Dermorphin
Peptide therapy: benefits, side effects, cost and protocols
C40H50N8O10
Dermorphin is a heptapeptide first isolated from the skin of South American frogs. It is a potent mu-opioid receptor agonist with approximately 30-40 times the analgesic potency of morphine. It is unique as one of the few naturally occurring D-amino acid-containing peptides.
Sources: FDA / PubMed / ClinicalTrials.gov View
Spec sheet
- FDA status
- Research Only Not currently approved for human use in the US. Available as a research compound. Not eligible for compounding.
- Evidence
- Emerging Evidence
Who it's for
Who Dermorphin is usually considered for
- Pain relief research
- Analgesic studies
- Primarily animal or early-phase data
Mechanism
How Dermorphin works
Selective mu-opioid receptor agonist with significant analgesic potency.
Evidence
Key studies
586 papers on PubMed / 70 human trials
- 01
In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin-Ranatensin Hybrid Peptide
- 02
Hochrainer N, Serafin P, D'Ingiullo S et al
Int J Mol Sci / Animal
- 03
LENART01 hybrid peptide showed superior antinociceptive effects versus morphine with reduced adverse effects and withdrawal syndrome
- 04
Peripheral mu-opioid receptor activation by dermorphin [D-Arg2, Lys4] (1-4) amide alleviates behavioral and neurobiological aberrations in rat model of chemotherapy-induced neuropathic pain
- 05
Gadepalli A, Ummadisetty O, Akhilesh et al
Neurotherapeutics / Animal
- 06
DALDA reduced chemotherapy-induced neuropathic pain without central side effects in rats
- 07
Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo)
- 08
Bird MF, Cerlesi MC, Brown M et al
PLoS One / Animal
- 09
DeNo, a novel Mu-NOP peptide agonist, displayed weak antinociceptive properties in rat models
- 10
Tolerance and physical dependence induced by dermorphin in rats
Compound
Dermorphin compound data
- Formula
- C40H50N8O10
- Mol. weight
- 802.9 g/mol
- PubChem CID
- 5485199 ↗
- IUPAC
- (2S)-N-[(1S)-2-amino-1-(hydroxymethyl)-2-oxo-ethyl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide
FAQ
Dermorphin questions
What is DERMORPHIN?
Dermorphin is a naturally occurring opioid peptide originally isolated from frog skin, researched for its potent analgesic properties.
How does DERMORPHIN work?
Selective mu-opioid receptor agonist with significant analgesic potency.
Is DERMORPHIN legal to buy?
DERMORPHIN is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.
Where can I buy DERMORPHIN?
DERMORPHIN is available as a research compound from verified online vendors. Always verify third-party testing before purchasing.
What category does DERMORPHIN belong to?
DERMORPHIN is primarily classified as a sexual function & libido peptide. Peptides researched for their effects on sexual function, libido, and reproductive health.
What are the research benefits of DERMORPHIN?
DERMORPHIN has been studied for: Pain relief research, Analgesic studies. Opioid-like; niche research peptide.
News
Dermorphin in the news
Analysing Opioid Peptide Demorphine in Equine Urine - AZoM
AZoM / 168 months ago
Antimicrobial peptides in frog poisons constitute a molecular toxin delivery system against predators - Nature
Nature / 108 months ago
Louisiana Veterinarian Sent to Prison for Providing Misbranded Veterinary Drugs to Racehorses - Partnership for Safe Medicines
Partnership for Safe Medicines / 104 months ago
Frog Skin Yields Potent Painkillers, but None Clinic Ready - www.the-scientist.com
www.the-scientist.com / 106 months ago
The Biological Effects of Kambo: Is There a Relationship Between its Administration and Sudden Death? - Wiley Online Library
Wiley Online Library / 110 months ago
News aggregated via Google News. Inclusion does not imply endorsement.
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