Weight Loss & MetabolicStrong Evidence

Cagrilintide Peptide Therapy

Benefits, Side Effects, Cost & Protocols

Cagrilintide peptide molecular structure diagram from PubChem

Cagrilintide is a long-acting analogue of amylin being tested for obesity and type 2 diabetes treatment, both alone and in combination with semaglutide (CagriSema) for enhanced weight loss efficacy.

ByChris Riley(CFA)&Alex Evans, PharmD, MBA(PharmD, MBA)|Updated May 19, 2026

Clinically Reviewed

Reviewed by Alex Evans, PharmD, MBA · Updated May 2026

Evidence-Based

Sourced from FDA, PubMed & ClinicalTrials.gov · View sources

FDA Status

Research Only Not currently approved for human use in the US. Available as a research compound. Not eligible for compounding.

Evidence

Strong Evidence

Who Is Cagrilintide Best For?

Appetite regulationWeight management researchGlycemic control

How Cagrilintide Works

Amylin receptor agonist that may influence satiety signaling, slow gastric emptying, and reduce glucagon secretion.

Cagrilintide FAQ

What is CAGRILINTIDE?

Cagrilintide is a long-acting amylin analog researched for weight management. It works differently from GLP-1 agonists and is often studied in combination with other peptides.

How does CAGRILINTIDE work?

Amylin receptor agonist that may influence satiety signaling, slow gastric emptying, and reduce glucagon secretion.

Is CAGRILINTIDE legal to buy?

CAGRILINTIDE is sold as a research chemical for laboratory use only. It is not approved for human use by the FDA. Regulations vary by jurisdiction.

Where can I buy CAGRILINTIDE?

CAGRILINTIDE is available as a research compound from verified online vendors. Always verify third-party testing before purchasing.

What category does CAGRILINTIDE belong to?

CAGRILINTIDE is primarily classified as a weight loss & metabolic peptide. Peptides researched for their effects on weight management, fat metabolism, appetite regulation, and metabolic enhancement. This category includes GLP-1 agonists, dual/triple agonists, and other metabolic peptides.

What are the research benefits of CAGRILINTIDE?

CAGRILINTIDE has been studied for: Appetite regulation, Weight management research, Glycemic control. Amylin analog; often researched in combination protocols.

Key Studies

75 total on PubMed0

CagriSema Reduces Blood Pressure in Adults With Overweight or Obesity: REDEFINE 1

Verma S, Böttcher M, Brown P et al

HypertensionPhase 3

CagriSema reduced systolic BP by 10.9 mmHg versus 2.8 mmHg with placebo at week 68.

CagriSema reduced systolic BP by 10.9 mmHg versus 2.8 mmHg with placebo at week 68

Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity

Garvey WT, Blüher M, Osorto Contreras CK et al

N Engl J MedPhase 3

Cagrilintide-semaglutide achieved 20.4% weight loss vs 3.0% placebo in adults with overweight/obesity.

Cagrilintide-semaglutide achieved 20.4% weight loss vs 3.0% placebo in adults with overweight/obesity

Cagrilintide-Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes

Davies MJ, Bajaj HS, Broholm C et al

N Engl J MedPhase 3

Cagrilintide-semaglutide reduced body weight by 13.7% vs 3.4% placebo in type 2 diabetes.

Cagrilintide-semaglutide reduced body weight by 13.7% vs 3.4% placebo in type 2 diabetes

Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial

Cagrilintide Compound Data

Molecular Formula

C194H312N54O59S2

Molecular Weight

4409 g/mol

IUPAC Name

20-[[(1S)-4-[[(1S)-5-amino-1-[[(4R,7S,10S,13S,16S,19R)-4-[[(1S)-2-[[(1S,2R)-1-[[(1S)-4-amino-1-[[(1S)-1-[[(1R)-1-[[(1R)-2-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-3-amino-1-[[(1S)-3-amino-1-[[(1S)-2-[[2-[(2S)-2-[[(1S,2S)-1-[[(1R)-1-[(2R)-2-[(2R)-2-[[(1R,2S)-1-[[(1R)-3-amino-1-[[(1R)-1-[[2-[[(1R)-2-[[(1R)-3-amino-1-[[(1R,2S)-1-[(2R)-2-carbamoylpyrrolidine-1-carbonyl]-2-hydroxy-propyl]carbamoyl]-3-oxo-propyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-oxo-propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]-3-methyl-butyl]carbamoyl]-2-methyl-butyl]carbamoyl]pyrrolidin-1-yl]-2-oxo-ethyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-3-oxo-propyl]carbamoyl]-3-oxo-propyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-3-carboxy-propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-4-oxo-butyl]carbamoyl]-2-hydroxy-propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-16-(2-amino-2-oxo-ethyl)-7,13-bis[(1R)-1-hydroxyethyl]-10-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]carbamoyl]pentyl]amino]-1-carboxy-4-oxo-butyl]amino]-20-oxo-icosanoic acid

View full compound on PubChem

Cagrilintide News

14 New Weight Loss Drugs - GoodRx

GoodRx · 2 days ago

Significant body weight reduction with cagrilintide-semaglutide therapy - 2 Minute Medicine

2 Minute Medicine · 8 months ago

Umbrella Labs Cagrilintide Peptide Research Use Only Program Expands Laboratory Access For High Rigor Amylin Receptor, Calcitonin Receptor, And Neuroendocrine Signaling Bench Science - ACCESS Newswire

ACCESS Newswire · 3 months ago

Weight loss: New drug CagriSema leads to 14% weight loss in trial - Medical News Today

Medical News Today · 3 months ago

CagriSema drives weight loss in rats by reducing energy intake and preserving energy expenditure - Nature

Nature · 10 months ago

News aggregated via Google News. Inclusion does not imply endorsement.

Medical Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. Peptide therapies have not been evaluated by the FDA for most listed indications.All prices shown are estimates based on publicly available data and may not reflect current pricing — providers and brands set their own prices and can change them at any time. Always verify pricing directly with the provider before purchasing. Consult a licensed healthcare provider before starting any peptide protocol.

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